Local treatment of metastases plus systemic chemotherapy on overall survival of patients with metastatic nasopharyngeal carcinoma

Wenjun Liao, Jinlan He, Qiheng Gou, Baofeng Duan, Ping Ai, Lei Liu, Yanchu Li, Kexing Ren, Min Yao, Nianyong Chen

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Abstract

Background: To investigate the effect of local treatment of metastases on overall survival (OS) of patients with metastatic nasopharyngeal carcinoma (NPC). Methods: One hundred and forty-seven patients were included. The association between local treatment and OS was examined with propensity score matching (PSM) method. Results: In entire cohort, the median OS was significantly longer in patients with local treatment of metastases plus chemotherapy compared to those with chemotherapy alone (71.7 vs. 16.2 months; p < 0.001). In PSM cohort, similar OS benefit of patients with local treatment was observed (55.6 vs. 17.6 months; p = 0.011). The survival benefit of local treatment remained regardless of the number of metastatic lesions and metastatic sites. Patients received radiation doses of >60 Gy had longer OS than those who received less. Conclusions: Local treatment of metastases could improve OS of patients with metastatic NPC and could be considered in their treatment in addition to chemotherapy.

Original languageEnglish (US)
Pages (from-to)2423-2433
Number of pages11
JournalHead and Neck
Volume43
Issue number8
DOIs
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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