Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization

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Abstract

The rabbit (Oryctolagus cuniculus) α-like globin gene cluster (HBAC) contains several block duplications of ζ-, α-, and θ-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G+C-rich region within the most distal band of the chromosome.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalGenomics
Volume9
Issue number2
DOIs
StatePublished - Feb 1991

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Chromosomes, Human, Pair 6
Globins
Multigene Family
In Situ Hybridization
Rabbits
Chromosomes
Chromosomes, Human, Pair 16
Gene Duplication
Chromosome Mapping
Metaphase

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

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title = "Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization",
abstract = "The rabbit (Oryctolagus cuniculus) α-like globin gene cluster (HBAC) contains several block duplications of ζ-, α-, and θ-globin genes. Using in situ hybridizations to metaphase chromosome spreads, the gene cluster has been mapped to region q12 of chromosome 6. Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns. In both species, HBAC is in a very G+C-rich region within the most distal band of the chromosome.",
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Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization. / Xu, Jia; Hardison, Ross C.

In: Genomics, Vol. 9, No. 2, 02.1991, p. 362-365.

Research output: Contribution to journalArticle

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T1 - Localization of the α-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization

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