Localization of the β-like globin gene cluster and the genes for parathyroid hormone and c-harvey-ras 1 to region ql4v→q21 of rabbit chromosome 1 by in situ hybridization

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Abstract

The rabbit β -like globin gene cluster (HBBC). comprised ore. ε, γ-δ- and β -globin genes (HBE. HBG. HBD. and HBB. respectively), has been mapped to chromosome 1. region ql4→q21. by in situ hybridization using probes for rabbit HBE and HBG. Probes for the human parathyroid hormone gene (PTH) and the Harvey-ra.v 1 protooncogene (HRASI) also localize to this region by in situ hybridization. Thus, these genes are syntenic in lagomorphs as well as four other mammalian orders (primates, rodents, carnivores, and artiodactyls). The mapping data in rabbits provide further evidence that this synteny is strongly conserved in the evolution of mammalian chromosomes.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalCytogenetic and Genome Research
Volume52
Issue number3-4
DOIs
StatePublished - Jan 1 1989

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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