Long interspersed L1 repeats in rabbit DNA are homologous to L1 repeats of rodents and primates in an open-reading-frame region

G. W. Demers, K. Brech, R. C. Hardison

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Determination of the DNA sequence of a cluster of repetitive elements located 3' to the rabbit beta-1 globin gene shows that previously identified B, E, and D repeats are linked to form a long repeat. The B and E regions are homologous to the L1 long interspersed repeats of primates and rodents. Thus L1 repeats are widely dispersed in several different mammalian orders. The sequence similarity among L1 repeats from three species is limited to a long segment that contains extensive open reading frames. This conserved region is followed by a highly divergent segment that corresponds to a 3' untranslated region. The conservation of sequences in the open-reading-frame region coupled with the divergence of the untranslated region supports the hypothesis that the L1 repeats are derived from transcripts of a functional gene that encodes a protein.

Original languageEnglish (US)
Pages (from-to)179-190
Number of pages12
JournalMolecular biology and evolution
Volume3
Issue number3
StatePublished - Jan 1 1986

Fingerprint

primate
Primates
rodent
Open Reading Frames
open reading frames
Rodentia
rodents
rabbits
Rabbits
Untranslated Regions
DNA
beta-Globins
E region
gene
3' Untranslated Regions
3' untranslated regions
DNA Sequence Analysis
Genes
genes
divergence

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

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abstract = "Determination of the DNA sequence of a cluster of repetitive elements located 3' to the rabbit beta-1 globin gene shows that previously identified B, E, and D repeats are linked to form a long repeat. The B and E regions are homologous to the L1 long interspersed repeats of primates and rodents. Thus L1 repeats are widely dispersed in several different mammalian orders. The sequence similarity among L1 repeats from three species is limited to a long segment that contains extensive open reading frames. This conserved region is followed by a highly divergent segment that corresponds to a 3' untranslated region. The conservation of sequences in the open-reading-frame region coupled with the divergence of the untranslated region supports the hypothesis that the L1 repeats are derived from transcripts of a functional gene that encodes a protein.",
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Long interspersed L1 repeats in rabbit DNA are homologous to L1 repeats of rodents and primates in an open-reading-frame region. / Demers, G. W.; Brech, K.; Hardison, R. C.

In: Molecular biology and evolution, Vol. 3, No. 3, 01.01.1986, p. 179-190.

Research output: Contribution to journalArticle

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