Long-lasting neural and behavioral effects of iron deficiency in infancy

Betsy Lozoff, John Beard, James Connor, Barbara Felt, Michael Georgieff, Timothy Schallert

Research output: Contribution to journalReview article

559 Scopus citations

Abstract

Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.

Original languageEnglish (US)
Pages (from-to)S34-S43
JournalNutrition reviews
Volume64
Issue number5 SUPPL. 1
DOIs
StatePublished - Oct 26 2006

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Lozoff, B., Beard, J., Connor, J., Felt, B., Georgieff, M., & Schallert, T. (2006). Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutrition reviews, 64(5 SUPPL. 1), S34-S43. https://doi.org/10.1301/nr.2006.may.S34-S43