Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area: The Seven Northeastern Cities (SNEC) study

Xiao Wen Zeng, Elaina Vivian, Kahee A. Mohammed, Shailja Jakhar, Michael Vaughn, Jin Huang, Alan Zelicoff, Pamela Xaverius, Zhipeng Bai, Shao Lin, Yuan Tao Hao, Gunther Paul, Lidia Morawska, Si Quan Wang, Zhengmin Qian, Guang Hui Dong

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Abstract

Epidemiological studies have reported inconsistent and inconclusive associations between long-term exposure to ambient air pollution and lung function in children from Europe and America, where air pollution levels were typically low. The aim of the present study is to examine the relationship between air pollutants and lung function in children selected from heavily industrialized and polluted cities in northeastern China. During 2012, 6740 boys and girls aged 7-14 years were recruited in 24 districts of seven northeastern cities. Portable electronic spirometers were used to measure lung function. Four-year average concentrations of particulate matter with an aerodynamic diameter ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3) were measured at monitoring stations in the 24 districts. Two-staged regression models were used in the data analysis, controlling for covariates. Overall, for all subjects, the increased odds of lung function impairment associated with exposure to air pollutants, ranged from 5% (adjusted odds ratio [aOR] = 1.05; 95% confidence interval [CI] = 1.01, 1.10) for FVC < 85% predicted per 46.3 μg/m3 for O3 to 81% (aOR = 1.81; 95%CI = 1.44, 2.28) for FEV1 < 85% predicted per 30.6 μg/m3 for PM10. The linear regression models consistently showed a negative relationship between all air pollutants and lung function measures across subjects. There were significant interaction terms indicating gender differences for lung function impairment and pulmonary function from exposure to some pollutants (P < 0.10). In conclusion, long term exposure to high concentrations of ambient air pollution is associated with decreased pulmonary function and lung function impairment, and females appear to be more susceptible than males.

Original languageEnglish (US)
Pages (from-to)144-151
Number of pages8
JournalAtmospheric Environment
Volume138
DOIs
StatePublished - Aug 1 2016

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ambient air
atmospheric pollution
confidence interval
nitrogen dioxide
sulfur dioxide
aerodynamics
particulate matter
gender
ozone
city
exposure
pollutant
air pollutant

All Science Journal Classification (ASJC) codes

  • Environmental Science(all)
  • Atmospheric Science

Cite this

Zeng, Xiao Wen ; Vivian, Elaina ; Mohammed, Kahee A. ; Jakhar, Shailja ; Vaughn, Michael ; Huang, Jin ; Zelicoff, Alan ; Xaverius, Pamela ; Bai, Zhipeng ; Lin, Shao ; Hao, Yuan Tao ; Paul, Gunther ; Morawska, Lidia ; Wang, Si Quan ; Qian, Zhengmin ; Dong, Guang Hui. / Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area : The Seven Northeastern Cities (SNEC) study. In: Atmospheric Environment. 2016 ; Vol. 138. pp. 144-151.
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title = "Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area: The Seven Northeastern Cities (SNEC) study",
abstract = "Epidemiological studies have reported inconsistent and inconclusive associations between long-term exposure to ambient air pollution and lung function in children from Europe and America, where air pollution levels were typically low. The aim of the present study is to examine the relationship between air pollutants and lung function in children selected from heavily industrialized and polluted cities in northeastern China. During 2012, 6740 boys and girls aged 7-14 years were recruited in 24 districts of seven northeastern cities. Portable electronic spirometers were used to measure lung function. Four-year average concentrations of particulate matter with an aerodynamic diameter ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3) were measured at monitoring stations in the 24 districts. Two-staged regression models were used in the data analysis, controlling for covariates. Overall, for all subjects, the increased odds of lung function impairment associated with exposure to air pollutants, ranged from 5{\%} (adjusted odds ratio [aOR] = 1.05; 95{\%} confidence interval [CI] = 1.01, 1.10) for FVC < 85{\%} predicted per 46.3 μg/m3 for O3 to 81{\%} (aOR = 1.81; 95{\%}CI = 1.44, 2.28) for FEV1 < 85{\%} predicted per 30.6 μg/m3 for PM10. The linear regression models consistently showed a negative relationship between all air pollutants and lung function measures across subjects. There were significant interaction terms indicating gender differences for lung function impairment and pulmonary function from exposure to some pollutants (P < 0.10). In conclusion, long term exposure to high concentrations of ambient air pollution is associated with decreased pulmonary function and lung function impairment, and females appear to be more susceptible than males.",
author = "Zeng, {Xiao Wen} and Elaina Vivian and Mohammed, {Kahee A.} and Shailja Jakhar and Michael Vaughn and Jin Huang and Alan Zelicoff and Pamela Xaverius and Zhipeng Bai and Shao Lin and Hao, {Yuan Tao} and Gunther Paul and Lidia Morawska and Wang, {Si Quan} and Zhengmin Qian and Dong, {Guang Hui}",
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Zeng, XW, Vivian, E, Mohammed, KA, Jakhar, S, Vaughn, M, Huang, J, Zelicoff, A, Xaverius, P, Bai, Z, Lin, S, Hao, YT, Paul, G, Morawska, L, Wang, SQ, Qian, Z & Dong, GH 2016, 'Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area: The Seven Northeastern Cities (SNEC) study', Atmospheric Environment, vol. 138, pp. 144-151. https://doi.org/10.1016/j.atmosenv.2016.05.003

Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area : The Seven Northeastern Cities (SNEC) study. / Zeng, Xiao Wen; Vivian, Elaina; Mohammed, Kahee A.; Jakhar, Shailja; Vaughn, Michael; Huang, Jin; Zelicoff, Alan; Xaverius, Pamela; Bai, Zhipeng; Lin, Shao; Hao, Yuan Tao; Paul, Gunther; Morawska, Lidia; Wang, Si Quan; Qian, Zhengmin; Dong, Guang Hui.

In: Atmospheric Environment, Vol. 138, 01.08.2016, p. 144-151.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area

T2 - The Seven Northeastern Cities (SNEC) study

AU - Zeng, Xiao Wen

AU - Vivian, Elaina

AU - Mohammed, Kahee A.

AU - Jakhar, Shailja

AU - Vaughn, Michael

AU - Huang, Jin

AU - Zelicoff, Alan

AU - Xaverius, Pamela

AU - Bai, Zhipeng

AU - Lin, Shao

AU - Hao, Yuan Tao

AU - Paul, Gunther

AU - Morawska, Lidia

AU - Wang, Si Quan

AU - Qian, Zhengmin

AU - Dong, Guang Hui

PY - 2016/8/1

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N2 - Epidemiological studies have reported inconsistent and inconclusive associations between long-term exposure to ambient air pollution and lung function in children from Europe and America, where air pollution levels were typically low. The aim of the present study is to examine the relationship between air pollutants and lung function in children selected from heavily industrialized and polluted cities in northeastern China. During 2012, 6740 boys and girls aged 7-14 years were recruited in 24 districts of seven northeastern cities. Portable electronic spirometers were used to measure lung function. Four-year average concentrations of particulate matter with an aerodynamic diameter ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3) were measured at monitoring stations in the 24 districts. Two-staged regression models were used in the data analysis, controlling for covariates. Overall, for all subjects, the increased odds of lung function impairment associated with exposure to air pollutants, ranged from 5% (adjusted odds ratio [aOR] = 1.05; 95% confidence interval [CI] = 1.01, 1.10) for FVC < 85% predicted per 46.3 μg/m3 for O3 to 81% (aOR = 1.81; 95%CI = 1.44, 2.28) for FEV1 < 85% predicted per 30.6 μg/m3 for PM10. The linear regression models consistently showed a negative relationship between all air pollutants and lung function measures across subjects. There were significant interaction terms indicating gender differences for lung function impairment and pulmonary function from exposure to some pollutants (P < 0.10). In conclusion, long term exposure to high concentrations of ambient air pollution is associated with decreased pulmonary function and lung function impairment, and females appear to be more susceptible than males.

AB - Epidemiological studies have reported inconsistent and inconclusive associations between long-term exposure to ambient air pollution and lung function in children from Europe and America, where air pollution levels were typically low. The aim of the present study is to examine the relationship between air pollutants and lung function in children selected from heavily industrialized and polluted cities in northeastern China. During 2012, 6740 boys and girls aged 7-14 years were recruited in 24 districts of seven northeastern cities. Portable electronic spirometers were used to measure lung function. Four-year average concentrations of particulate matter with an aerodynamic diameter ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3) were measured at monitoring stations in the 24 districts. Two-staged regression models were used in the data analysis, controlling for covariates. Overall, for all subjects, the increased odds of lung function impairment associated with exposure to air pollutants, ranged from 5% (adjusted odds ratio [aOR] = 1.05; 95% confidence interval [CI] = 1.01, 1.10) for FVC < 85% predicted per 46.3 μg/m3 for O3 to 81% (aOR = 1.81; 95%CI = 1.44, 2.28) for FEV1 < 85% predicted per 30.6 μg/m3 for PM10. The linear regression models consistently showed a negative relationship between all air pollutants and lung function measures across subjects. There were significant interaction terms indicating gender differences for lung function impairment and pulmonary function from exposure to some pollutants (P < 0.10). In conclusion, long term exposure to high concentrations of ambient air pollution is associated with decreased pulmonary function and lung function impairment, and females appear to be more susceptible than males.

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