Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) after subchronic treatment in rats

K. H. Sontag, Christine Marcelle Heim, T. A. Sontag, R. God, H. Reichmann, W. Wesemann, W. D. Rausch, P. Riederer, G. Bringmann

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), which shows a great structural similarity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), when administered to rats lead to enhanced spontaneous locomotor activity and a reduction in the apomorphine-induced increase in locomotion when they were tested 4-9 days after subchronic injection at a daily dose of 0.2 mg/kg over a seven week period. However, 9 weeks after the end of the course of injections animals walked more slowly during 12 hours of nocturnal activity, and apomorphine-induced locomotion was decreased 12 weeks later. These results suggest that the drug may exert a progressive neurotoxic effect.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalJournal of Neural Transmission, Supplement
Issue number46
StatePublished - Dec 1 1995

Fingerprint

Carbolines
Locomotion
Apomorphine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Injections
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Sontag, K. H. ; Heim, Christine Marcelle ; Sontag, T. A. ; God, R. ; Reichmann, H. ; Wesemann, W. ; Rausch, W. D. ; Riederer, P. ; Bringmann, G. / Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) after subchronic treatment in rats. In: Journal of Neural Transmission, Supplement. 1995 ; No. 46. pp. 283-289.
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abstract = "1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), which shows a great structural similarity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), when administered to rats lead to enhanced spontaneous locomotor activity and a reduction in the apomorphine-induced increase in locomotion when they were tested 4-9 days after subchronic injection at a daily dose of 0.2 mg/kg over a seven week period. However, 9 weeks after the end of the course of injections animals walked more slowly during 12 hours of nocturnal activity, and apomorphine-induced locomotion was decreased 12 weeks later. These results suggest that the drug may exert a progressive neurotoxic effect.",
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Sontag, KH, Heim, CM, Sontag, TA, God, R, Reichmann, H, Wesemann, W, Rausch, WD, Riederer, P & Bringmann, G 1995, 'Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) after subchronic treatment in rats', Journal of Neural Transmission, Supplement, no. 46, pp. 283-289.

Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) after subchronic treatment in rats. / Sontag, K. H.; Heim, Christine Marcelle; Sontag, T. A.; God, R.; Reichmann, H.; Wesemann, W.; Rausch, W. D.; Riederer, P.; Bringmann, G.

In: Journal of Neural Transmission, Supplement, No. 46, 01.12.1995, p. 283-289.

Research output: Contribution to journalArticle

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AU - God, R.

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