Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) after subchronic treatment in rats

K. H. Sontag, Christine Marcelle Heim, T. A. Sontag, R. God, H. Reichmann, W. Wesemann, W. D. Rausch, P. Riederer, G. Bringmann

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19 Scopus citations

Abstract

1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo), which shows a great structural similarity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), when administered to rats lead to enhanced spontaneous locomotor activity and a reduction in the apomorphine-induced increase in locomotion when they were tested 4-9 days after subchronic injection at a daily dose of 0.2 mg/kg over a seven week period. However, 9 weeks after the end of the course of injections animals walked more slowly during 12 hours of nocturnal activity, and apomorphine-induced locomotion was decreased 12 weeks later. These results suggest that the drug may exert a progressive neurotoxic effect.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalJournal of Neural Transmission, Supplement
Issue number46
StatePublished - Dec 1 1995

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Sontag, K. H., Heim, C. M., Sontag, T. A., God, R., Reichmann, H., Wesemann, W., Rausch, W. D., Riederer, P., & Bringmann, G. (1995). Long-term behavioural effects of TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) after subchronic treatment in rats. Journal of Neural Transmission, Supplement, (46), 283-289.