Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine

J. A. Stoute, K. E. Kester, U. Krzych, B. T. Wellde, T. Hall, K. White, G. Glenn, C. F. Ockenhouse, N. Garcon, R. Schwenk, D. E. Lanar, P. Sun, P. Momin, R. A. Wirtz, C. Golenda, M. Slaoui, G. Wortmann, C. Holland, M. Dowler, J. CohenW. R. Ballou

Research output: Contribution to journalArticlepeer-review

212 Scopus citations

Abstract

The malaria sporozoite vaccine candidate RTS,S, formulated with an oil- in-water emulsion plus the immunostimulants monophosphoryl lipid A and the saponin derivative QS21 (vaccine 3), recently showed superior efficacy over two other experimental formulations. Immunized volunteers were followed to determine the duration of protective immune responses. Antibody levels decreased to between one-third and one-half of peak values 6 months after the last dose of vaccine. T cell proliferation and interferon-γ production in vitro were observed in response to RTS,S or hepatitis B surface antigen. Seven previously protected volunteers received sporozoite challenge, and 2 remained protected (1/1 for vaccine 1, 0/1 for vaccine 2, and 1/5 for vaccine 3). The prepatent period was 10.8 days for the control group and 13.2 days for the vaccinees (P < .01). Immune responses did not correlate with protection. Further optimization in vaccine composition and/or immunization schedule will be required to induce longer-lasting protective immunity.

Original languageEnglish (US)
Pages (from-to)1139-1144
Number of pages6
JournalJournal of Infectious Diseases
Volume178
Issue number4
DOIs
StatePublished - 1998

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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