TY - JOUR
T1 - Long-term exposure to ambient fine particulate matter and fasting blood glucose level in a Chinese elderly cohort
AU - Zhang, Yi
AU - Li, Tiantian
AU - Ma, Runmei
AU - Yin, Zhaoxue
AU - Wang, Jiaonan
AU - He, Mike Z.
AU - Xu, Dandan
AU - Gao, Xiang
AU - Wang, Qing
AU - Kraus, Virginia Byers
AU - Lv, Yuebin
AU - Zhong, Yu
AU - Kinney, Patrick L.
AU - Shi, Xiaoming
N1 - Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (Grant: 81273160, 81573247, 91543111), the National High-level Talents Special Support Plan of China for Young Talents, the National Institutes of Health Institutional Research T32 Training Grant (T32 ES023770), the National Institute of Environmental Health Sciences (NIEHS) Individual Fellowship Grant (F31 ES029372) and the National Institutes of Health (NIH) P30 NIH/NIA P30-AG028716 (to VBK).
Funding Information:
This work was supported by grants from the National Natural Science Foundation of China (Grant: 81273160 , 81573247 , 91543111 ), the National High-level Talents Special Support Plan of China for Young Talents , the National Institutes of Health Institutional Research T32 Training Grant ( T32 ES023770 ), the National Institute of Environmental Health Sciences (NIEHS) Individual Fellowship Grant (F31 ES029372) and the National Institutes of Health (NIH) P30 NIH/NIA P30-AG028716 (to VBK).
Publisher Copyright:
© 2020
PY - 2020/5/15
Y1 - 2020/5/15
N2 - Fasting blood glucose level is the primary indicator for the diagnosis of diabetes. We aim to conduct a longitudinal study on the association between long-term fine particulate matter (PM2.5) exposure and fasting blood glucose concentrations. We recruited and followed up 1449 participants older than 65 years of age in 2009, 2012, 2014, and 2017 in eight counties in China. Fasting blood glucose was repeatedly measured 3697 times in total among these participants. Data on annual ground-level PM2.5 concentrations with a 0.01° spatial resolution from 2005 to 2016 were used to assess exposures. An increase of 10 μg/m3 in 3-year average exposure to PM2.5 was associated with an increase of 0.146 mmol/L (95% confidence interval [CI]: 0.045, 0.248) in fasting blood glucose in all participants. The association was more pronounced among the subgroup with diabetes compared to the subgroup without diabetes (P < .05). In conclusion, Long-term PM2.5 exposure was associated with an increase in fasting blood glucose levels among elderly people. Elderly individuals with diabetes are particularly vulnerable to high level exposures of PM2.5. Long-term PM2.5 exposure was associated with an increase in fasting blood glucose levels among elderly people. Elderly individuals with diabetes are particularly vulnerable to high level exposures of PM2.5.
AB - Fasting blood glucose level is the primary indicator for the diagnosis of diabetes. We aim to conduct a longitudinal study on the association between long-term fine particulate matter (PM2.5) exposure and fasting blood glucose concentrations. We recruited and followed up 1449 participants older than 65 years of age in 2009, 2012, 2014, and 2017 in eight counties in China. Fasting blood glucose was repeatedly measured 3697 times in total among these participants. Data on annual ground-level PM2.5 concentrations with a 0.01° spatial resolution from 2005 to 2016 were used to assess exposures. An increase of 10 μg/m3 in 3-year average exposure to PM2.5 was associated with an increase of 0.146 mmol/L (95% confidence interval [CI]: 0.045, 0.248) in fasting blood glucose in all participants. The association was more pronounced among the subgroup with diabetes compared to the subgroup without diabetes (P < .05). In conclusion, Long-term PM2.5 exposure was associated with an increase in fasting blood glucose levels among elderly people. Elderly individuals with diabetes are particularly vulnerable to high level exposures of PM2.5. Long-term PM2.5 exposure was associated with an increase in fasting blood glucose levels among elderly people. Elderly individuals with diabetes are particularly vulnerable to high level exposures of PM2.5.
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U2 - 10.1016/j.scitotenv.2020.137191
DO - 10.1016/j.scitotenv.2020.137191
M3 - Article
C2 - 32062280
AN - SCOPUS:85079233850
SN - 0048-9697
VL - 717
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 137191
ER -