Long-term potentiation in the hippocampal slice: Evidence for stimulated secretion of newly synthesized proteins

Charles Duffy, Timothy J. Teyler, Victor E. Shashoua

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Long-term potentiation of the hippocampal slice preparation results in an increase in the incorporation of labeled valine into the proteins destined for secretion into the extracellular medium. Double-labeling methods established that the increased secretion of the labeled proteins was limited to the potentiated region of a slice; incorporation of labeled valine was increased in the hippocampus if potentiation was through the Schaffer collaterals and in the dentate if potentiation was through the perforant path. Controls for nonspecific stimulation showed no changes. There appears to be a link between long-term potentiation and the metabolic processes that lead to protein synthesis in the hippocampal slice system.

Original languageEnglish (US)
Pages (from-to)1148-1151
Number of pages4
JournalScience
Volume212
Issue number4499
DOIs
StatePublished - Jan 1 1981

All Science Journal Classification (ASJC) codes

  • General

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