Long-term sleep laboratory evaluation of flunitrazepam

M. B. Scharf, E. O. Bixler, A. Kales, C. R. Soldatos

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A sleep laboratory hypnotic drug evaluation study was conducted in which 2 mg flunitrazepam, a benzodiazepine with a half life of intermediate duration, was administered nightly to 6 insomniac subjects for 4 consecutive weeks. The drug was effective with short-term use. However, tolerance developed for sleep maintenance during the intermediate- and long-term drug administration periods. Following drug withdrawal, a significant worsening of sleep above baseline levels occurred. These data are consistent with our previous findings of rebound insomnia following withdrawal of short- and intermediate-acting benzodiazepines.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalPharmacology
Volume19
Issue number4
DOIs
StatePublished - Jan 1 1979

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Flunitrazepam
Sleep
Benzodiazepines
Pharmaceutical Preparations
Drug Evaluation
Sleep Initiation and Maintenance Disorders
Hypnotics and Sedatives
Half-Life
Maintenance

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Scharf, M. B., Bixler, E. O., Kales, A., & Soldatos, C. R. (1979). Long-term sleep laboratory evaluation of flunitrazepam. Pharmacology, 19(4), 173-181. https://doi.org/10.1159/000137306
Scharf, M. B. ; Bixler, E. O. ; Kales, A. ; Soldatos, C. R. / Long-term sleep laboratory evaluation of flunitrazepam. In: Pharmacology. 1979 ; Vol. 19, No. 4. pp. 173-181.
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Scharf, MB, Bixler, EO, Kales, A & Soldatos, CR 1979, 'Long-term sleep laboratory evaluation of flunitrazepam', Pharmacology, vol. 19, no. 4, pp. 173-181. https://doi.org/10.1159/000137306

Long-term sleep laboratory evaluation of flunitrazepam. / Scharf, M. B.; Bixler, E. O.; Kales, A.; Soldatos, C. R.

In: Pharmacology, Vol. 19, No. 4, 01.01.1979, p. 173-181.

Research output: Contribution to journalArticle

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Scharf MB, Bixler EO, Kales A, Soldatos CR. Long-term sleep laboratory evaluation of flunitrazepam. Pharmacology. 1979 Jan 1;19(4):173-181. https://doi.org/10.1159/000137306