Longer Tc-99m-mebrofenin labeling-to-administration time results in scintigraphic underestimation of liver function

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Tc-99m-mebrofenin clearance rate is used to estimate hepatocellular function. This investigation studied effect of labeling-to-administration (LTA) time of Tc-99m-mebrofenin and its liver clearance rate. Methods: A total of 15 patients, age 46 ± 13 (range, 19-69) years, referred for routine gallbladder ejection fraction testing, were retrospectively studied. All had tests associated to normal liver, and no medical history of liver diseases was observed. Tc-99m-mebrofenin scintigraphic liver clearance (MSLC) rate was determined by the standard technique based on liver uptake rate. The radiopharmaceutical was prepared at an off-site central radiopharmacy. Linear regression was used to assess relationship of LTA time and MSLC. Results: The LTA was 7.6 ± 2.0 (range, 4-12) hours. The labeling efficiency was 99.0% ± 1.33%. The MSLC rate was 11.9%/min ± 2.7%/min (range, 6.4-18.3). There was an inverse relationship of LTA and MSLC, expressed in the following equation: y = -0. 97x + 19.25 (R2 = 0.5076, P = 0.0028). The negative correlation with LTA remained when MSLC was corrected for body surface area (R2 = 0.4241, P = 0.0085). Conclusion: There is a significant underestimation of MSLC with increasing LTA time. If liver function assessment is the purpose of a hepatobiliary study, Tc-99m-mebrofenin should be administered as close to the time of radiopharmaceutical preparation as possible, preferably within 1 hour.

Original languageEnglish (US)
Pages (from-to)1079-1085
Number of pages7
JournalClinical nuclear medicine
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2011

Fingerprint

Liver
Radiopharmaceuticals
Body Surface Area
Gallbladder
Liver Diseases
Linear Models

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{ef36505a59cc43c28df8d2568b541f09,
title = "Longer Tc-99m-mebrofenin labeling-to-administration time results in scintigraphic underestimation of liver function",
abstract = "Objective: Tc-99m-mebrofenin clearance rate is used to estimate hepatocellular function. This investigation studied effect of labeling-to-administration (LTA) time of Tc-99m-mebrofenin and its liver clearance rate. Methods: A total of 15 patients, age 46 ± 13 (range, 19-69) years, referred for routine gallbladder ejection fraction testing, were retrospectively studied. All had tests associated to normal liver, and no medical history of liver diseases was observed. Tc-99m-mebrofenin scintigraphic liver clearance (MSLC) rate was determined by the standard technique based on liver uptake rate. The radiopharmaceutical was prepared at an off-site central radiopharmacy. Linear regression was used to assess relationship of LTA time and MSLC. Results: The LTA was 7.6 ± 2.0 (range, 4-12) hours. The labeling efficiency was 99.0{\%} ± 1.33{\%}. The MSLC rate was 11.9{\%}/min ± 2.7{\%}/min (range, 6.4-18.3). There was an inverse relationship of LTA and MSLC, expressed in the following equation: y = -0. 97x + 19.25 (R2 = 0.5076, P = 0.0028). The negative correlation with LTA remained when MSLC was corrected for body surface area (R2 = 0.4241, P = 0.0085). Conclusion: There is a significant underestimation of MSLC with increasing LTA time. If liver function assessment is the purpose of a hepatobiliary study, Tc-99m-mebrofenin should be administered as close to the time of radiopharmaceutical preparation as possible, preferably within 1 hour.",
author = "Mark Tulchinsky and Thomas Allen",
year = "2011",
month = "12",
day = "1",
doi = "10.1097/RLU.0b013e3182336234",
language = "English (US)",
volume = "36",
pages = "1079--1085",
journal = "Clinical Nuclear Medicine",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Longer Tc-99m-mebrofenin labeling-to-administration time results in scintigraphic underestimation of liver function

AU - Tulchinsky, Mark

AU - Allen, Thomas

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Objective: Tc-99m-mebrofenin clearance rate is used to estimate hepatocellular function. This investigation studied effect of labeling-to-administration (LTA) time of Tc-99m-mebrofenin and its liver clearance rate. Methods: A total of 15 patients, age 46 ± 13 (range, 19-69) years, referred for routine gallbladder ejection fraction testing, were retrospectively studied. All had tests associated to normal liver, and no medical history of liver diseases was observed. Tc-99m-mebrofenin scintigraphic liver clearance (MSLC) rate was determined by the standard technique based on liver uptake rate. The radiopharmaceutical was prepared at an off-site central radiopharmacy. Linear regression was used to assess relationship of LTA time and MSLC. Results: The LTA was 7.6 ± 2.0 (range, 4-12) hours. The labeling efficiency was 99.0% ± 1.33%. The MSLC rate was 11.9%/min ± 2.7%/min (range, 6.4-18.3). There was an inverse relationship of LTA and MSLC, expressed in the following equation: y = -0. 97x + 19.25 (R2 = 0.5076, P = 0.0028). The negative correlation with LTA remained when MSLC was corrected for body surface area (R2 = 0.4241, P = 0.0085). Conclusion: There is a significant underestimation of MSLC with increasing LTA time. If liver function assessment is the purpose of a hepatobiliary study, Tc-99m-mebrofenin should be administered as close to the time of radiopharmaceutical preparation as possible, preferably within 1 hour.

AB - Objective: Tc-99m-mebrofenin clearance rate is used to estimate hepatocellular function. This investigation studied effect of labeling-to-administration (LTA) time of Tc-99m-mebrofenin and its liver clearance rate. Methods: A total of 15 patients, age 46 ± 13 (range, 19-69) years, referred for routine gallbladder ejection fraction testing, were retrospectively studied. All had tests associated to normal liver, and no medical history of liver diseases was observed. Tc-99m-mebrofenin scintigraphic liver clearance (MSLC) rate was determined by the standard technique based on liver uptake rate. The radiopharmaceutical was prepared at an off-site central radiopharmacy. Linear regression was used to assess relationship of LTA time and MSLC. Results: The LTA was 7.6 ± 2.0 (range, 4-12) hours. The labeling efficiency was 99.0% ± 1.33%. The MSLC rate was 11.9%/min ± 2.7%/min (range, 6.4-18.3). There was an inverse relationship of LTA and MSLC, expressed in the following equation: y = -0. 97x + 19.25 (R2 = 0.5076, P = 0.0028). The negative correlation with LTA remained when MSLC was corrected for body surface area (R2 = 0.4241, P = 0.0085). Conclusion: There is a significant underestimation of MSLC with increasing LTA time. If liver function assessment is the purpose of a hepatobiliary study, Tc-99m-mebrofenin should be administered as close to the time of radiopharmaceutical preparation as possible, preferably within 1 hour.

UR - http://www.scopus.com/inward/record.url?scp=80955139463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80955139463&partnerID=8YFLogxK

U2 - 10.1097/RLU.0b013e3182336234

DO - 10.1097/RLU.0b013e3182336234

M3 - Article

C2 - 22064076

AN - SCOPUS:80955139463

VL - 36

SP - 1079

EP - 1085

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

SN - 0363-9762

IS - 12

ER -