Longitudinal impact of substance use and depressive symptoms on bone accrual among girls aged 11-19 years

Lorah D. Dorn, Sarah J. Beal, Heidi J. Kalkwarf, Stephanie Pabst, Jennie G. Noll, Elizabeth J. Susman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose: Osteoporosis is primarily evident in postmenopausal women, but its roots are traceable to periods of growth, including during adolescence. Depression, anxiety, and smoking are associated with lower bone mineral density (BMD) in adults. These associations have not been studied longitudinally across adolescence, when more than 50% of bone accrual occurs. Methods: To determine the impact of depressive and anxiety symptoms, smoking, and alcohol use on bone accrual in girls 11-19 years, 262 healthy girls were enrolled in age cohorts of 11, 13, 15, and 17 years. Using a cross-sequential design, girls were seen for three annual visits. Outcome measures included total body bone mineral content and BMD of the total hip and lumbar spine using dual energy x-ray absorptiometry. Depressive and anxiety symptoms and smoking and alcohol use were by self-report. Results: Higher-frequency smoking was associated with a lower rate of lumbar spine and total hip BMD accrual from ages 13-19. Higher depressive symptoms were associated with lower lumbar spine BMD across 11-19 years of age. There was no effect of depressive symptoms on total body bone mineral content, and there was no effect of alcohol intake on any bone outcome. Conclusion: Adolescent smokers are at higher risk for less than optimal bone accrual. Even in the absence of diagnosable depression, depressive symptoms may influence adolescent bone accrual. These findings have import for prevention of later osteoporosis and fractures.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalJournal of Adolescent Health
Volume52
Issue number4
DOIs
StatePublished - Apr 1 2013

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Bone Density
Depression
Bone and Bones
Smoking
Spine
Anxiety
Alcohols
Osteoporosis
Pelvic Bones
Self Report
Hip
X-Rays
Outcome Assessment (Health Care)
Growth

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health

Cite this

Dorn, Lorah D. ; Beal, Sarah J. ; Kalkwarf, Heidi J. ; Pabst, Stephanie ; Noll, Jennie G. ; Susman, Elizabeth J. / Longitudinal impact of substance use and depressive symptoms on bone accrual among girls aged 11-19 years. In: Journal of Adolescent Health. 2013 ; Vol. 52, No. 4. pp. 393-399.
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Longitudinal impact of substance use and depressive symptoms on bone accrual among girls aged 11-19 years. / Dorn, Lorah D.; Beal, Sarah J.; Kalkwarf, Heidi J.; Pabst, Stephanie; Noll, Jennie G.; Susman, Elizabeth J.

In: Journal of Adolescent Health, Vol. 52, No. 4, 01.04.2013, p. 393-399.

Research output: Contribution to journalArticle

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