Longterm management of Polycystic Ovarian Syndrome (PCOS)

Gordon W. Bates, Richard Legro

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Polycystic Ovarian Syndrome (PCOS) has been associated with numerous reproductive and metabolic abnormalities. Despite tremendous advances in the management of reproductive dysfunction, insight into the metabolic implications of PCOS is limited by the lack of uniform diagnostic criteria, the heterogeneity of the condition and the presence of confounders including obesity. Obesity clearly has a role in long term health and may best predict both reproductive and metabolic dysfunction as well as negatively affect the response to treatment in women with PCOS. Diabetes, cardiovascular disease and cancer are also at the forefront of any risk assessment or comprehensive treatment strategy for these women. Lifestyle modifications including dietary changes, increased exercise and weight loss are appropriate first line interventions for many women with PCOS. Pharmaceuticals including metformin, lipid lowering agents and oral contraceptives should be tailored to the individual's risk profile and treatment goals.

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume373
Issue number1-2
DOIs
StatePublished - Jul 5 2013

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Polycystic Ovary Syndrome
Metformin
Medical problems
Oral Contraceptives
Risk assessment
Health
Lipids
Pharmaceutical Preparations
Obesity
Diet Therapy
Life Style
Weight Loss
Cardiovascular Diseases
Therapeutics
Exercise
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

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Longterm management of Polycystic Ovarian Syndrome (PCOS). / Bates, Gordon W.; Legro, Richard.

In: Molecular and Cellular Endocrinology, Vol. 373, No. 1-2, 05.07.2013, p. 91-97.

Research output: Contribution to journalReview article

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