Loss of G protein γ7 alters behavior and reduces striatal αolf level and cAMP production

William F. Schwindinger, Kelly S. Betz, Kathryn E. Giger, Angela Sabol, Sarah K. Bronson, Janet D. Robishaw

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

The G protein βγ-dimer is required for receptor interaction and effector regulation. However, previous approaches have not identified the physiologic roles of individual subtypes in these processes. We used a gene knockout approach to demonstrate a unique role for the G protein γ7-subunit in mice. Notably, deletion of Gng7 caused behavioral changes that were associated with reductions in the αolf-subunit content and adenylyl cyclase activity of the striatum. These data demonstrate that an individual γ-subunit contributes to the specificity of a given signaling pathway and controls the formation or stability of a particular G protein heterotrimer.

Original languageEnglish (US)
Pages (from-to)6575-6579
Number of pages5
JournalJournal of Biological Chemistry
Volume278
Issue number8
DOIs
StatePublished - Feb 21 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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