Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model

T. C. Montie, D. Doyle Huntzinger, Rebecca Craven, I. A. Holder

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To test the importance of flagella as a virulence factor, virulent strain Pseudomonas aeruginosa M-2 was mutagenized, and a Fla- mutant was isolated. An M-2 Fla- spontaneous motile revertant was isolated from M-2 Fla-. The three strains were biochemically and morphologically identical. Assay of Fla+ in the burned-mouse model showed a severe loss of virulence. The Fla+ revertant was fully virulent. The immportance of P. aeruginosa motility (flagella) for virulence in burns infections is indicated.

Original languageEnglish (US)
Pages (from-to)1296-1298
Number of pages3
JournalInfection and Immunity
Issue number3
Publication statusPublished - 1982


All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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