Low bone density risk is higher in exercising women with multiple triad risk factors

Jenna C. Gibbs, Aurelia Nattiv, Michelle T. Barrack, Nancy Williams, Mitchell J. Rauh, Jeanne F. Nichols, Mary Jane De Souza

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The cumulative effect of the female athlete triad (Triad) risk factors on the likelihood of low bone mineral density (BMD) in exercising women is unclear. PURPOSE: This study aimed to determine the risk of low BMD in exercising women with multiple Triad risk factors. METHODS: We retrospectively examined cross-sectional data from 437 exercising women (mean ± SD age of 18.0 ± 3.5 yr, weighed 57.5 ± 7.1 kg with 24.5% ± 6.1% body fat) obtained at baseline from 4 prospective cohort studies examining Triad risk factors. Questionnaires were completed to obtain information on demographic characteristics, self-reported eating attitudes/behaviors, menstrual function, sport/activity participation, and medication use. Height and body weight were measured. BMD was measured using dual energy x-ray absorptiometry. Low BMD was defined as z-scores of <-1 and ≤-2. Chi-square tests were performed to determine the percentage of women with low BMD who met the criteria for individual (current oligo/amenorrhea, late menarche, low body mass index (BMI), elevated dietary restraint, lean sport/activity participation) or multiple (2, 3, 4, or 5) Triad risk factors. RESULTS: Late menarche and low BMI were associated with the highest percentage of low BMD (z-score < -1), 55% and 54%, respectively, and low BMD (z-score ≤-2), 14% and 16%, respectively. The percentage of participants with low BMD (z-score < -1 and ≤-2) increased from 10% to 62% and from 2% to 18%, respectively, as women met the criteria for an increasing number of Triad risk factors. CONCLUSIONS: A cumulative number of Triad risk factors were associated with an increased risk of low BMD, suggesting a dose-response association between the number of Triad risk factors and BMD in exercising women. Further research should be conducted to develop a user-friendly algorithm integrating these indicators of risk for low BMD in exercising women (particularly factors associated with low BMI/body weight, menstrual dysfunction, lean sport/activity participation, and elevated dietary restraint).

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalMedicine and Science in Sports and Exercise
Volume46
Issue number1
DOIs
StatePublished - Jan 1 2014

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Bone Density
Sports
Menarche
Body Mass Index
Female Athlete Triad Syndrome
Body Weight
Amenorrhea
Feeding Behavior
Chi-Square Distribution
Adipose Tissue
Cohort Studies
X-Rays
Demography
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Gibbs, Jenna C. ; Nattiv, Aurelia ; Barrack, Michelle T. ; Williams, Nancy ; Rauh, Mitchell J. ; Nichols, Jeanne F. ; De Souza, Mary Jane. / Low bone density risk is higher in exercising women with multiple triad risk factors. In: Medicine and Science in Sports and Exercise. 2014 ; Vol. 46, No. 1. pp. 167-176.
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abstract = "The cumulative effect of the female athlete triad (Triad) risk factors on the likelihood of low bone mineral density (BMD) in exercising women is unclear. PURPOSE: This study aimed to determine the risk of low BMD in exercising women with multiple Triad risk factors. METHODS: We retrospectively examined cross-sectional data from 437 exercising women (mean ± SD age of 18.0 ± 3.5 yr, weighed 57.5 ± 7.1 kg with 24.5{\%} ± 6.1{\%} body fat) obtained at baseline from 4 prospective cohort studies examining Triad risk factors. Questionnaires were completed to obtain information on demographic characteristics, self-reported eating attitudes/behaviors, menstrual function, sport/activity participation, and medication use. Height and body weight were measured. BMD was measured using dual energy x-ray absorptiometry. Low BMD was defined as z-scores of <-1 and ≤-2. Chi-square tests were performed to determine the percentage of women with low BMD who met the criteria for individual (current oligo/amenorrhea, late menarche, low body mass index (BMI), elevated dietary restraint, lean sport/activity participation) or multiple (2, 3, 4, or 5) Triad risk factors. RESULTS: Late menarche and low BMI were associated with the highest percentage of low BMD (z-score < -1), 55{\%} and 54{\%}, respectively, and low BMD (z-score ≤-2), 14{\%} and 16{\%}, respectively. The percentage of participants with low BMD (z-score < -1 and ≤-2) increased from 10{\%} to 62{\%} and from 2{\%} to 18{\%}, respectively, as women met the criteria for an increasing number of Triad risk factors. CONCLUSIONS: A cumulative number of Triad risk factors were associated with an increased risk of low BMD, suggesting a dose-response association between the number of Triad risk factors and BMD in exercising women. Further research should be conducted to develop a user-friendly algorithm integrating these indicators of risk for low BMD in exercising women (particularly factors associated with low BMI/body weight, menstrual dysfunction, lean sport/activity participation, and elevated dietary restraint).",
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Low bone density risk is higher in exercising women with multiple triad risk factors. / Gibbs, Jenna C.; Nattiv, Aurelia; Barrack, Michelle T.; Williams, Nancy; Rauh, Mitchell J.; Nichols, Jeanne F.; De Souza, Mary Jane.

In: Medicine and Science in Sports and Exercise, Vol. 46, No. 1, 01.01.2014, p. 167-176.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low bone density risk is higher in exercising women with multiple triad risk factors

AU - Gibbs, Jenna C.

AU - Nattiv, Aurelia

AU - Barrack, Michelle T.

AU - Williams, Nancy

AU - Rauh, Mitchell J.

AU - Nichols, Jeanne F.

AU - De Souza, Mary Jane

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N2 - The cumulative effect of the female athlete triad (Triad) risk factors on the likelihood of low bone mineral density (BMD) in exercising women is unclear. PURPOSE: This study aimed to determine the risk of low BMD in exercising women with multiple Triad risk factors. METHODS: We retrospectively examined cross-sectional data from 437 exercising women (mean ± SD age of 18.0 ± 3.5 yr, weighed 57.5 ± 7.1 kg with 24.5% ± 6.1% body fat) obtained at baseline from 4 prospective cohort studies examining Triad risk factors. Questionnaires were completed to obtain information on demographic characteristics, self-reported eating attitudes/behaviors, menstrual function, sport/activity participation, and medication use. Height and body weight were measured. BMD was measured using dual energy x-ray absorptiometry. Low BMD was defined as z-scores of <-1 and ≤-2. Chi-square tests were performed to determine the percentage of women with low BMD who met the criteria for individual (current oligo/amenorrhea, late menarche, low body mass index (BMI), elevated dietary restraint, lean sport/activity participation) or multiple (2, 3, 4, or 5) Triad risk factors. RESULTS: Late menarche and low BMI were associated with the highest percentage of low BMD (z-score < -1), 55% and 54%, respectively, and low BMD (z-score ≤-2), 14% and 16%, respectively. The percentage of participants with low BMD (z-score < -1 and ≤-2) increased from 10% to 62% and from 2% to 18%, respectively, as women met the criteria for an increasing number of Triad risk factors. CONCLUSIONS: A cumulative number of Triad risk factors were associated with an increased risk of low BMD, suggesting a dose-response association between the number of Triad risk factors and BMD in exercising women. Further research should be conducted to develop a user-friendly algorithm integrating these indicators of risk for low BMD in exercising women (particularly factors associated with low BMI/body weight, menstrual dysfunction, lean sport/activity participation, and elevated dietary restraint).

AB - The cumulative effect of the female athlete triad (Triad) risk factors on the likelihood of low bone mineral density (BMD) in exercising women is unclear. PURPOSE: This study aimed to determine the risk of low BMD in exercising women with multiple Triad risk factors. METHODS: We retrospectively examined cross-sectional data from 437 exercising women (mean ± SD age of 18.0 ± 3.5 yr, weighed 57.5 ± 7.1 kg with 24.5% ± 6.1% body fat) obtained at baseline from 4 prospective cohort studies examining Triad risk factors. Questionnaires were completed to obtain information on demographic characteristics, self-reported eating attitudes/behaviors, menstrual function, sport/activity participation, and medication use. Height and body weight were measured. BMD was measured using dual energy x-ray absorptiometry. Low BMD was defined as z-scores of <-1 and ≤-2. Chi-square tests were performed to determine the percentage of women with low BMD who met the criteria for individual (current oligo/amenorrhea, late menarche, low body mass index (BMI), elevated dietary restraint, lean sport/activity participation) or multiple (2, 3, 4, or 5) Triad risk factors. RESULTS: Late menarche and low BMI were associated with the highest percentage of low BMD (z-score < -1), 55% and 54%, respectively, and low BMD (z-score ≤-2), 14% and 16%, respectively. The percentage of participants with low BMD (z-score < -1 and ≤-2) increased from 10% to 62% and from 2% to 18%, respectively, as women met the criteria for an increasing number of Triad risk factors. CONCLUSIONS: A cumulative number of Triad risk factors were associated with an increased risk of low BMD, suggesting a dose-response association between the number of Triad risk factors and BMD in exercising women. Further research should be conducted to develop a user-friendly algorithm integrating these indicators of risk for low BMD in exercising women (particularly factors associated with low BMI/body weight, menstrual dysfunction, lean sport/activity participation, and elevated dietary restraint).

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