TY - GEN
T1 - Low-cost photoacoustic computed tomography system using light-emitting-diodes
AU - Agrawal, Sumit
AU - Yang, Xinyi
AU - Albahrani, Hussain
AU - Fadden, Christopher
AU - Dangi, Ajay
AU - Singh, Mithun Kuniyil Ajith
AU - Kothapalli, Sri Rajasekhar
N1 - Funding Information:
This project was partially funded by the NIH-NIBIB R00EB017729-04 (SRK) and Penn State Cancer Institute (SRK). We also acknowledge the support of NVIDIA Corporation with the donation of the Titan X Pascal GPU used for the reconstruction of LED-PAT images. We further thank CYBERDYNE Inc. for their technical support.
Publisher Copyright:
© 2020 SPIE.
PY - 2020
Y1 - 2020
N2 - Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.
AB - Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.
UR - http://www.scopus.com/inward/record.url?scp=85082689238&partnerID=8YFLogxK
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U2 - 10.1117/12.2546993
DO - 10.1117/12.2546993
M3 - Conference contribution
AN - SCOPUS:85082689238
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
A2 - Oraevsky, Alexander A.
A2 - Wang, Lihong V.
PB - SPIE
T2 - Photons Plus Ultrasound: Imaging and Sensing 2020
Y2 - 2 February 2020 through 5 February 2020
ER -
