Low-cost photoacoustic computed tomography system using light-emitting-diodes

Sumit Agrawal, Xinyi Yang, Hussain Albahrani, Christopher Fadden, Ajay Dangi, Mithun Kuniyil Ajith Singh, Sri Rajasekhar Kothapalli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Photoacoustic computed tomography (PACT) has been widely explored for studying human diseases as well as response to therapies. Most PACT systems employ a large footprint, bulky, and high-cost lasers. Light emitting diodes (LEDs) based B-mode photoacoustic imaging systems have emerged as a low cost and compact alternative, offering a unique opportunity to expedite the widespread adoption of photoacoustic imaging in clinical and resource-poor settings. The high pulse repetition rate of LEDs facilitates signal-to-noise ratio improvements through averaging in spite of lower pulse energy. Here, we present the development of first low-cost LED-based PACT system that uses multiple LED arrays and a linear ultrasound transducer to generate three-dimensional structural, functional and molecular images of the object. Similar to OPO based lasers, our LED-PACT system allows for the multi-wavelength photoacoustic imaging vital for mapping functional and molecular information. Our experiments demonstrate that this study will enable clinical and pre-clinical applications such as imaging human arthritis and whole body mouse imaging.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2020
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510632431
DOIs
StatePublished - Jan 1 2020
EventPhotons Plus Ultrasound: Imaging and Sensing 2020 - San Francisco, United States
Duration: Feb 2 2020Feb 5 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11240
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2020
CountryUnited States
CitySan Francisco
Period2/2/202/5/20

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Agrawal, S., Yang, X., Albahrani, H., Fadden, C., Dangi, A., Singh, M. K. A., & Kothapalli, S. R. (2020). Low-cost photoacoustic computed tomography system using light-emitting-diodes. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2020 [1124058] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11240). SPIE. https://doi.org/10.1117/12.2546993