Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis

Zachary Simmons, Mila Blaivas, Arnold J. Aguilera, Eva L. Feldman, Mark B. Bromberg, Javad Towfighi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Patients with primary amyloidosis may develop peripheral neuropathy as an early feature. Sural nerve biopsy is reported to be a sensitive method for diagnosing amyloidosis in such patients. We identified nine patients, ultimately diagnosed as having amyloidosis, who were referred for peripheral neuropathy of undetermined etiology. In six, a sural nerve biopsy demonstrated no amyloid. Subsequent examination of other tissue or of the contralateral sural nerve eventually resulted in the correct diagnosis. We conclude that sural nerve biopsy may be less sensitive than previously believed for the diagnosis of amyloidosis in patients with peripheral neuropathy secondary to amyloid. When the clinical suspicion of amyloidosis is high, a nondiagnostic sural nerve biopsy should not discourage the performance of further investigative studies.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalJournal of the neurological sciences
Volume120
Issue number1
DOIs
StatePublished - Dec 1 1993

Fingerprint

Sural Nerve
Peripheral Nervous System Diseases
Amyloidosis
Biopsy
Amyloid
Primary amyloidosis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Simmons, Zachary ; Blaivas, Mila ; Aguilera, Arnold J. ; Feldman, Eva L. ; Bromberg, Mark B. ; Towfighi, Javad. / Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis. In: Journal of the neurological sciences. 1993 ; Vol. 120, No. 1. pp. 60-63.
@article{e1cf451181fd4d7dbe0cf0b16174a5a8,
title = "Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis",
abstract = "Patients with primary amyloidosis may develop peripheral neuropathy as an early feature. Sural nerve biopsy is reported to be a sensitive method for diagnosing amyloidosis in such patients. We identified nine patients, ultimately diagnosed as having amyloidosis, who were referred for peripheral neuropathy of undetermined etiology. In six, a sural nerve biopsy demonstrated no amyloid. Subsequent examination of other tissue or of the contralateral sural nerve eventually resulted in the correct diagnosis. We conclude that sural nerve biopsy may be less sensitive than previously believed for the diagnosis of amyloidosis in patients with peripheral neuropathy secondary to amyloid. When the clinical suspicion of amyloidosis is high, a nondiagnostic sural nerve biopsy should not discourage the performance of further investigative studies.",
author = "Zachary Simmons and Mila Blaivas and Aguilera, {Arnold J.} and Feldman, {Eva L.} and Bromberg, {Mark B.} and Javad Towfighi",
year = "1993",
month = "12",
day = "1",
doi = "10.1016/0022-510X(93)90025-T",
language = "English (US)",
volume = "120",
pages = "60--63",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1",

}

Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis. / Simmons, Zachary; Blaivas, Mila; Aguilera, Arnold J.; Feldman, Eva L.; Bromberg, Mark B.; Towfighi, Javad.

In: Journal of the neurological sciences, Vol. 120, No. 1, 01.12.1993, p. 60-63.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis

AU - Simmons, Zachary

AU - Blaivas, Mila

AU - Aguilera, Arnold J.

AU - Feldman, Eva L.

AU - Bromberg, Mark B.

AU - Towfighi, Javad

PY - 1993/12/1

Y1 - 1993/12/1

N2 - Patients with primary amyloidosis may develop peripheral neuropathy as an early feature. Sural nerve biopsy is reported to be a sensitive method for diagnosing amyloidosis in such patients. We identified nine patients, ultimately diagnosed as having amyloidosis, who were referred for peripheral neuropathy of undetermined etiology. In six, a sural nerve biopsy demonstrated no amyloid. Subsequent examination of other tissue or of the contralateral sural nerve eventually resulted in the correct diagnosis. We conclude that sural nerve biopsy may be less sensitive than previously believed for the diagnosis of amyloidosis in patients with peripheral neuropathy secondary to amyloid. When the clinical suspicion of amyloidosis is high, a nondiagnostic sural nerve biopsy should not discourage the performance of further investigative studies.

AB - Patients with primary amyloidosis may develop peripheral neuropathy as an early feature. Sural nerve biopsy is reported to be a sensitive method for diagnosing amyloidosis in such patients. We identified nine patients, ultimately diagnosed as having amyloidosis, who were referred for peripheral neuropathy of undetermined etiology. In six, a sural nerve biopsy demonstrated no amyloid. Subsequent examination of other tissue or of the contralateral sural nerve eventually resulted in the correct diagnosis. We conclude that sural nerve biopsy may be less sensitive than previously believed for the diagnosis of amyloidosis in patients with peripheral neuropathy secondary to amyloid. When the clinical suspicion of amyloidosis is high, a nondiagnostic sural nerve biopsy should not discourage the performance of further investigative studies.

UR - http://www.scopus.com/inward/record.url?scp=0027721944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027721944&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(93)90025-T

DO - 10.1016/0022-510X(93)90025-T

M3 - Article

C2 - 7507161

AN - SCOPUS:0027721944

VL - 120

SP - 60

EP - 63

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1

ER -