Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L.

A. Ruvinsky, A. Polyakov, A. Agulnik, H. Tichy, F. Figueroa, J. Klein

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Abstract

In previous studies, 13 different recessive embryonic lethal genes have been associated with t haplotypes in the wild mice of the species Mus domesticus. In this communication we have analyzed five populations of Mus musculus for the presence and identity of t haplotypes. The populations occupy geographically distant regions in the Soviet Union: Altai Mountains, western and eastern Siberia, Azerbaijan and Turkmenistan. No t haplotypes were found in mice from eastern Siberia. In the remaining four populations, t haplotypes occurred with frequencies ranging from 0.07 to 0.21. All the t haplotypes extracted from these populations and analyzed by the genetic complementation test were shown to carry the same lethal gene tcl-w73. In one population (that of western Siberia), another lethal gene (tcl-w5) was found to be present on the same chromosome as tcl-w73. This situation is in striking contrast to that found in the populations of the western form of the house mouse, M. domesticus. In the latter species, tcl-w73 has not been found at all and the different populations are characterized by the presence of several different lethal genes. The low diversity of t haplotypes in M. musculus is consistent with lower genetic variability of other traits and indicates a different origin and speciation mode compared to M. domesticus. Serological typing for H-2 antigenic determinants suggests that most, if not all, of the newly described t haplotypes might have arisen by recombination of t(w73) from M. musculus with t haplotypes from M. domesticus either in the hybrid zone between the two species or in regions where the two species mixed accidentally.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalGenetics
Volume127
Issue number1
StatePublished - 1991

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Haplotypes
Lethal Genes
Siberia
Population
Turkmenistan
Azerbaijan
Genetic Complementation Test
USSR
Population Genetics
Genetic Recombination
Epitopes
Chromosomes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Ruvinsky, A., Polyakov, A., Agulnik, A., Tichy, H., Figueroa, F., & Klein, J. (1991). Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. Genetics, 127(1), 161-168.
Ruvinsky, A. ; Polyakov, A. ; Agulnik, A. ; Tichy, H. ; Figueroa, F. ; Klein, J. / Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. In: Genetics. 1991 ; Vol. 127, No. 1. pp. 161-168.
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Ruvinsky, A, Polyakov, A, Agulnik, A, Tichy, H, Figueroa, F & Klein, J 1991, 'Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L.', Genetics, vol. 127, no. 1, pp. 161-168.

Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. / Ruvinsky, A.; Polyakov, A.; Agulnik, A.; Tichy, H.; Figueroa, F.; Klein, J.

In: Genetics, Vol. 127, No. 1, 1991, p. 161-168.

Research output: Contribution to journalArticle

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AU - Ruvinsky, A.

AU - Polyakov, A.

AU - Agulnik, A.

AU - Tichy, H.

AU - Figueroa, F.

AU - Klein, J.

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Y1 - 1991

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Ruvinsky A, Polyakov A, Agulnik A, Tichy H, Figueroa F, Klein J. Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L. Genetics. 1991;127(1):161-168.