Low energy availability in exercising men is associated with reduced leptin and insulin but not with changes in other metabolic hormones

Karsten Koehler, Neele R. Hoerner, Jenna C. Gibbs, Christoph Zinner, Hans Braun, Mary Jane De Souza, Wilhelm Schaenzer

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

ABSTRACT: Low energy availability, defined as low caloric intake relative to exercise energy expenditure, has been linked to endocrine alterations frequently observed in chronically energy-deficient exercising women. Our goal was to determine the endocrine effects of low energy availability in exercising men. Six exercising men (VO 2peak : 49.3 ± 2.4 ml · kg −1 · min −1 ) underwent two conditions of low energy availability (15 kcal · kg −1 fat-free mass [FFM] · day −1 ) and two energy-balanced conditions (40 kcal · kg −1 FFM · day −1 ) in randomised order. During one low energy availability and one balanced condition, participants exercised to expend 15 kcal · kg −1 FFM · day −1 ; no exercise was conducted during the other two conditions. Metabolic hormones were assessed before and after each 4-day period. Following both low energy availability conditions, leptin (−53% to −56%) and insulin (−34% to −38%) were reduced (P < 0.05). Reductions in leptin and insulin were independent of whether low energy availability was attained with or without exercise (P > 0.80). Low energy availability did not significantly impact ghrelin, triiodothyronine, testosterone and IGF-1 (all P > 0.05). The observed reductions in leptin and insulin were in the same magnitude as changes previously reported in sedentary women. Further research is needed to understand why other metabolic hormones are more robust against low energy availability in exercising men than those in sedentary and exercising women.

Original languageEnglish (US)
Pages (from-to)1921-1929
Number of pages9
JournalJournal of Sports Sciences
Volume34
Issue number20
DOIs
StatePublished - Oct 17 2016

Fingerprint

Leptin
Fats
Hormones
Insulin
Exercise
Ghrelin
Triiodothyronine
Energy Intake
Insulin-Like Growth Factor I
Energy Metabolism
Testosterone
Research

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Koehler, Karsten ; Hoerner, Neele R. ; Gibbs, Jenna C. ; Zinner, Christoph ; Braun, Hans ; De Souza, Mary Jane ; Schaenzer, Wilhelm. / Low energy availability in exercising men is associated with reduced leptin and insulin but not with changes in other metabolic hormones. In: Journal of Sports Sciences. 2016 ; Vol. 34, No. 20. pp. 1921-1929.
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abstract = "ABSTRACT: Low energy availability, defined as low caloric intake relative to exercise energy expenditure, has been linked to endocrine alterations frequently observed in chronically energy-deficient exercising women. Our goal was to determine the endocrine effects of low energy availability in exercising men. Six exercising men (VO 2peak : 49.3 ± 2.4 ml · kg −1 · min −1 ) underwent two conditions of low energy availability (15 kcal · kg −1 fat-free mass [FFM] · day −1 ) and two energy-balanced conditions (40 kcal · kg −1 FFM · day −1 ) in randomised order. During one low energy availability and one balanced condition, participants exercised to expend 15 kcal · kg −1 FFM · day −1 ; no exercise was conducted during the other two conditions. Metabolic hormones were assessed before and after each 4-day period. Following both low energy availability conditions, leptin (−53{\%} to −56{\%}) and insulin (−34{\%} to −38{\%}) were reduced (P < 0.05). Reductions in leptin and insulin were independent of whether low energy availability was attained with or without exercise (P > 0.80). Low energy availability did not significantly impact ghrelin, triiodothyronine, testosterone and IGF-1 (all P > 0.05). The observed reductions in leptin and insulin were in the same magnitude as changes previously reported in sedentary women. Further research is needed to understand why other metabolic hormones are more robust against low energy availability in exercising men than those in sedentary and exercising women.",
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Low energy availability in exercising men is associated with reduced leptin and insulin but not with changes in other metabolic hormones. / Koehler, Karsten; Hoerner, Neele R.; Gibbs, Jenna C.; Zinner, Christoph; Braun, Hans; De Souza, Mary Jane; Schaenzer, Wilhelm.

In: Journal of Sports Sciences, Vol. 34, No. 20, 17.10.2016, p. 1921-1929.

Research output: Contribution to journalArticle

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AU - Koehler, Karsten

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AU - Schaenzer, Wilhelm

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