Abstract
Low-density lipoprotein cholesterol (LDL-C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL-C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu-Asia Aging Study) for whom the LDL-C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow-up, 41 men developed PD (18.4/ 10,000 person-years). Although the incidence of PD increased with decreasing LDL-C in a dose-dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person-years in men with LDL-C levels <80 mg/dl to less than 9/ 10,000 person-years for concentrations that were ≥140 mg/ dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL-C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1013-1018 |
| Number of pages | 6 |
| Journal | Movement Disorders |
| Volume | 23 |
| Issue number | 7 |
| DOIs | |
| State | Published - May 15 2008 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
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Low LDL cholesterol and increased risk of Parkinson's disease : Prospective results from Honolulu-Asia aging study. / Huang, Xuemei; Abbott, Robert D.; Petrovitch, Helen; Mailman, Richard B.; Ross, G. Webster.
In: Movement Disorders, Vol. 23, No. 7, 15.05.2008, p. 1013-1018.Research output: Contribution to journal › Article
TY - JOUR
T1 - Low LDL cholesterol and increased risk of Parkinson's disease
T2 - Prospective results from Honolulu-Asia aging study
AU - Huang, Xuemei
AU - Abbott, Robert D.
AU - Petrovitch, Helen
AU - Mailman, Richard B.
AU - Ross, G. Webster
PY - 2008/5/15
Y1 - 2008/5/15
N2 - Low-density lipoprotein cholesterol (LDL-C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL-C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu-Asia Aging Study) for whom the LDL-C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow-up, 41 men developed PD (18.4/ 10,000 person-years). Although the incidence of PD increased with decreasing LDL-C in a dose-dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person-years in men with LDL-C levels <80 mg/dl to less than 9/ 10,000 person-years for concentrations that were ≥140 mg/ dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL-C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD.
AB - Low-density lipoprotein cholesterol (LDL-C) levels are suggested to be associated inversely with Parkinson's disease (PD). To test the hypothesis that LDL-C levels may increase PD risk, we studied a prospective cohort of 3,233 men (Honolulu-Asia Aging Study) for whom the LDL-C from fasting lipid profiles was obtained during 1991 to 1993. The cohort was followed longitudinally until 2001 for incident Parkinson's cases. During follow-up, 41 men developed PD (18.4/ 10,000 person-years). Although the incidence of PD increased with decreasing LDL-C in a dose-dependent manner, the association was only significant for men aged 71 to 75 years. In the latter group, risk of PD declined from 38.5/10,000 person-years in men with LDL-C levels <80 mg/dl to less than 9/ 10,000 person-years for concentrations that were ≥140 mg/ dl. After adjustment for age, smoking, coffee intake, and other factors, the relative odds of PD for men at the 80th versus the 20th percentile of LDL-C (135 vs. 85 mg/dl) was 0.4 (95% confidence interval: 0.2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD.
UR - http://www.scopus.com/inward/record.url?scp=49249129009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49249129009&partnerID=8YFLogxK
U2 - 10.1002/mds.22013
DO - 10.1002/mds.22013
M3 - Article
C2 - 18381649
AN - SCOPUS:49249129009
VL - 23
SP - 1013
EP - 1018
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 7
ER -