Low temperature synthesis of a self-assembling composite: Hydroxyapatite-poly[bis(sodium carboxylatophenoxy)phosphazene]

K. S. Tenhuisen, P. W. Brown, C. S. Reed, Harry R. Allcock

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The present study was undertaken to investigate the low temperature formation of a hydroxyapatite-polyphosphazene polymer composite likely to be biocompatible. The temperature range studied (25 to 60°C) was selected to bracket physiological temperatures. The composite precursors consisted of CaHP04·2H20, Ca4(P04)20, and poly[bis(sodium carboxylatophenoxy)phosphazene]. The results indicate that a synergistic relationship exists in the formation of a polyphosphazene network and hydroxyapatite (HAp) matrix phase during composite synthesis. Calcium from the HAp precursors participates in the formation of a Ca crosslinked polymeric network which influences the rate of HAp formation and its morphology. The mechanistic paths taken during composite formation were followed by determining variations in the concentration of species in solution (at physiological temperature), rates of heat evolution, and microstructural development. These analyses indicate that the polymer controls the kinetics of hydroxyapatite formation and the composite microstructure. Low reaction temperatures and a high proportion of polymer facilitate the formation of a highly interconnected composite. The presence of the polyphosphazene allows a metastable calcium phosphate solution to persist for extended periods prior to the formation of hydroxyapatite. The degree of supersaturation and the length of the induction period increase with an increase in polyphosphazene content. The temperature dependence of these induction periods obeyed an Arrhenius relationship.

Original languageEnglish (US)
Pages (from-to)673-682
Number of pages10
JournalJournal of Materials Science: Materials in Medicine
Volume7
Issue number11
DOIs
StatePublished - Nov 1996

Fingerprint

Durapatite
Hydroxyapatite
Sodium
Temperature
Composite materials
Polymers
Supersaturation
Calcium phosphate
Calcium
Hot Temperature
Microstructure
Kinetics
poly(phosphazene)

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

@article{1839a78474c84894a5baee2eb96bb2b7,
title = "Low temperature synthesis of a self-assembling composite: Hydroxyapatite-poly[bis(sodium carboxylatophenoxy)phosphazene]",
abstract = "The present study was undertaken to investigate the low temperature formation of a hydroxyapatite-polyphosphazene polymer composite likely to be biocompatible. The temperature range studied (25 to 60°C) was selected to bracket physiological temperatures. The composite precursors consisted of CaHP04·2H20, Ca4(P04)20, and poly[bis(sodium carboxylatophenoxy)phosphazene]. The results indicate that a synergistic relationship exists in the formation of a polyphosphazene network and hydroxyapatite (HAp) matrix phase during composite synthesis. Calcium from the HAp precursors participates in the formation of a Ca crosslinked polymeric network which influences the rate of HAp formation and its morphology. The mechanistic paths taken during composite formation were followed by determining variations in the concentration of species in solution (at physiological temperature), rates of heat evolution, and microstructural development. These analyses indicate that the polymer controls the kinetics of hydroxyapatite formation and the composite microstructure. Low reaction temperatures and a high proportion of polymer facilitate the formation of a highly interconnected composite. The presence of the polyphosphazene allows a metastable calcium phosphate solution to persist for extended periods prior to the formation of hydroxyapatite. The degree of supersaturation and the length of the induction period increase with an increase in polyphosphazene content. The temperature dependence of these induction periods obeyed an Arrhenius relationship.",
author = "Tenhuisen, {K. S.} and Brown, {P. W.} and Reed, {C. S.} and Allcock, {Harry R.}",
year = "1996",
month = "11",
doi = "10.1007/BF00123406",
language = "English (US)",
volume = "7",
pages = "673--682",
journal = "Journal of Materials Science: Materials in Electronics",
issn = "0957-4522",
publisher = "Springer New York",
number = "11",

}

Low temperature synthesis of a self-assembling composite : Hydroxyapatite-poly[bis(sodium carboxylatophenoxy)phosphazene]. / Tenhuisen, K. S.; Brown, P. W.; Reed, C. S.; Allcock, Harry R.

In: Journal of Materials Science: Materials in Medicine, Vol. 7, No. 11, 11.1996, p. 673-682.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low temperature synthesis of a self-assembling composite

T2 - Hydroxyapatite-poly[bis(sodium carboxylatophenoxy)phosphazene]

AU - Tenhuisen, K. S.

AU - Brown, P. W.

AU - Reed, C. S.

AU - Allcock, Harry R.

PY - 1996/11

Y1 - 1996/11

N2 - The present study was undertaken to investigate the low temperature formation of a hydroxyapatite-polyphosphazene polymer composite likely to be biocompatible. The temperature range studied (25 to 60°C) was selected to bracket physiological temperatures. The composite precursors consisted of CaHP04·2H20, Ca4(P04)20, and poly[bis(sodium carboxylatophenoxy)phosphazene]. The results indicate that a synergistic relationship exists in the formation of a polyphosphazene network and hydroxyapatite (HAp) matrix phase during composite synthesis. Calcium from the HAp precursors participates in the formation of a Ca crosslinked polymeric network which influences the rate of HAp formation and its morphology. The mechanistic paths taken during composite formation were followed by determining variations in the concentration of species in solution (at physiological temperature), rates of heat evolution, and microstructural development. These analyses indicate that the polymer controls the kinetics of hydroxyapatite formation and the composite microstructure. Low reaction temperatures and a high proportion of polymer facilitate the formation of a highly interconnected composite. The presence of the polyphosphazene allows a metastable calcium phosphate solution to persist for extended periods prior to the formation of hydroxyapatite. The degree of supersaturation and the length of the induction period increase with an increase in polyphosphazene content. The temperature dependence of these induction periods obeyed an Arrhenius relationship.

AB - The present study was undertaken to investigate the low temperature formation of a hydroxyapatite-polyphosphazene polymer composite likely to be biocompatible. The temperature range studied (25 to 60°C) was selected to bracket physiological temperatures. The composite precursors consisted of CaHP04·2H20, Ca4(P04)20, and poly[bis(sodium carboxylatophenoxy)phosphazene]. The results indicate that a synergistic relationship exists in the formation of a polyphosphazene network and hydroxyapatite (HAp) matrix phase during composite synthesis. Calcium from the HAp precursors participates in the formation of a Ca crosslinked polymeric network which influences the rate of HAp formation and its morphology. The mechanistic paths taken during composite formation were followed by determining variations in the concentration of species in solution (at physiological temperature), rates of heat evolution, and microstructural development. These analyses indicate that the polymer controls the kinetics of hydroxyapatite formation and the composite microstructure. Low reaction temperatures and a high proportion of polymer facilitate the formation of a highly interconnected composite. The presence of the polyphosphazene allows a metastable calcium phosphate solution to persist for extended periods prior to the formation of hydroxyapatite. The degree of supersaturation and the length of the induction period increase with an increase in polyphosphazene content. The temperature dependence of these induction periods obeyed an Arrhenius relationship.

UR - http://www.scopus.com/inward/record.url?scp=0030296367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030296367&partnerID=8YFLogxK

U2 - 10.1007/BF00123406

DO - 10.1007/BF00123406

M3 - Article

AN - SCOPUS:0030296367

VL - 7

SP - 673

EP - 682

JO - Journal of Materials Science: Materials in Electronics

JF - Journal of Materials Science: Materials in Electronics

SN - 0957-4522

IS - 11

ER -