Lower pulmonary function and cerebral subclinical abnormalities detected by MRI: The atherosclerosis risk in communities study

Duanping Liao, Millicent Higgins, Nick R. Bryan, Marsha L. Eigenbrodt, Lloyd E. Chambless, Verna Lamar, Gregory L. Burke, Gerardo Heiss

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Study objectives: To investigate the association between pulmonary function and (1) cerebral infarction and (2) white matter lesions (WMLs), identified by MRI and believed to represent subclinical lesions of arteriosclerosis, generalized hypoperfusion, or ischemia of the brain. Design: Population-based, cross-sectional study. Setting: Two communities in the United States. Participants: A sample of 1,917 African-American and white men and women 55 to 72 years old who were selected from the second follow-up examination of the Atherosclerosis Risk in Communities Study cohort. Interventions: Observational study. Measurements and results: The lung function indexes, FEV1 and FVC, were assessed according to American Thoracic Society criteria. Subclinical cerebral infarction and WMLs were assessed by MRI. After adjusting for age, ethnicity, gender, height, and height squared, a 1-SD decrease of FEV1 in nonsmokers was associated with odds ratios (95% confidence interval [CI], 1.31 to 2.03) of 1.63 for infarction and 1.35(95% CI, 1,08 to 1.69) for WMLs. Of those in the lowest quartile of FEV1 15% had infarction and WMLs, in contrast to 6% of the individuals in the uppermost quartile of FEV1. Consistent associations were also observed by using FVC as an index of pulmonary function. Similar patterns of association were found among current smokers. The associations were not altered by additional adjustment of conventional risk factors of cardiovascular disease, comorbidity, or cognitive function Conclusion: The results from this population-based study suggest that lower pulmonary function is associated with subclinical cerebral abnormalities.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalCHEST
Volume116
Issue number1
DOIs
StatePublished - Jan 1 1999

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Atherosclerosis
Lung
Cerebral Infarction
Infarction
Confidence Intervals
Social Adjustment
Arteriosclerosis
Brain Ischemia
African Americans
Cognition
Population
Observational Studies
Comorbidity
Cohort Studies
Cardiovascular Diseases
Cross-Sectional Studies
Odds Ratio
White Matter

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Liao, D., Higgins, M., Bryan, N. R., Eigenbrodt, M. L., Chambless, L. E., Lamar, V., ... Heiss, G. (1999). Lower pulmonary function and cerebral subclinical abnormalities detected by MRI: The atherosclerosis risk in communities study. CHEST, 116(1), 150-156. https://doi.org/10.1378/chest.116.1.150
Liao, Duanping ; Higgins, Millicent ; Bryan, Nick R. ; Eigenbrodt, Marsha L. ; Chambless, Lloyd E. ; Lamar, Verna ; Burke, Gregory L. ; Heiss, Gerardo. / Lower pulmonary function and cerebral subclinical abnormalities detected by MRI : The atherosclerosis risk in communities study. In: CHEST. 1999 ; Vol. 116, No. 1. pp. 150-156.
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Liao, D, Higgins, M, Bryan, NR, Eigenbrodt, ML, Chambless, LE, Lamar, V, Burke, GL & Heiss, G 1999, 'Lower pulmonary function and cerebral subclinical abnormalities detected by MRI: The atherosclerosis risk in communities study', CHEST, vol. 116, no. 1, pp. 150-156. https://doi.org/10.1378/chest.116.1.150

Lower pulmonary function and cerebral subclinical abnormalities detected by MRI : The atherosclerosis risk in communities study. / Liao, Duanping; Higgins, Millicent; Bryan, Nick R.; Eigenbrodt, Marsha L.; Chambless, Lloyd E.; Lamar, Verna; Burke, Gregory L.; Heiss, Gerardo.

In: CHEST, Vol. 116, No. 1, 01.01.1999, p. 150-156.

Research output: Contribution to journalArticle

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T1 - Lower pulmonary function and cerebral subclinical abnormalities detected by MRI

T2 - The atherosclerosis risk in communities study

AU - Liao, Duanping

AU - Higgins, Millicent

AU - Bryan, Nick R.

AU - Eigenbrodt, Marsha L.

AU - Chambless, Lloyd E.

AU - Lamar, Verna

AU - Burke, Gregory L.

AU - Heiss, Gerardo

PY - 1999/1/1

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N2 - Study objectives: To investigate the association between pulmonary function and (1) cerebral infarction and (2) white matter lesions (WMLs), identified by MRI and believed to represent subclinical lesions of arteriosclerosis, generalized hypoperfusion, or ischemia of the brain. Design: Population-based, cross-sectional study. Setting: Two communities in the United States. Participants: A sample of 1,917 African-American and white men and women 55 to 72 years old who were selected from the second follow-up examination of the Atherosclerosis Risk in Communities Study cohort. Interventions: Observational study. Measurements and results: The lung function indexes, FEV1 and FVC, were assessed according to American Thoracic Society criteria. Subclinical cerebral infarction and WMLs were assessed by MRI. After adjusting for age, ethnicity, gender, height, and height squared, a 1-SD decrease of FEV1 in nonsmokers was associated with odds ratios (95% confidence interval [CI], 1.31 to 2.03) of 1.63 for infarction and 1.35(95% CI, 1,08 to 1.69) for WMLs. Of those in the lowest quartile of FEV1 15% had infarction and WMLs, in contrast to 6% of the individuals in the uppermost quartile of FEV1. Consistent associations were also observed by using FVC as an index of pulmonary function. Similar patterns of association were found among current smokers. The associations were not altered by additional adjustment of conventional risk factors of cardiovascular disease, comorbidity, or cognitive function Conclusion: The results from this population-based study suggest that lower pulmonary function is associated with subclinical cerebral abnormalities.

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