LTR retroelement-derived protein-coding genes and vertebrate evolution

Domitille Chalopin, Marta Hoover, Delphine Galiana, Jean Nicolas Volff

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

During evolution, many cellular protein-coding genes have been formed from genes carried by long terminal repeat (LTR) retroelements (retroviruses and LTR retrotransposons). This phenomenon, called molecular domestication, has significantly impacted the emergence and diversification of the vertebrate lineage. LTR retroelements have contributed different types of coding regions to the gene repertoire of their host, including gag, envelope, integrase and protease genes. Genes derived from gag and envelope sequences are particularly well represented in vertebrate genomes. Retroelement-derived genes fulfil functions in important -biological processes, particularly placenta formation and immunity against retro-elements, as well as cell proliferation and apoptosis. Of particular interest is the recurrent molecular domestication of retrovirus envelope genes, which has taken place several times independently in different mammalian sublineages to generate new genes involved in placenta formation. The function of most retroelement-derived genes remains unknown, and additional new genes are still to be identified particularly in lower vertebrates.

Original languageEnglish (US)
Title of host publicationViruses
Subtitle of host publicationEssential Agents of Life
PublisherSpringer Netherlands
Pages269-282
Number of pages14
Volume9789400748996
ISBN (Electronic)9789400748996
ISBN (Print)9400748981, 9789400748989
DOIs
StatePublished - Nov 1 2012

Fingerprint

Retroelements
terminal repeat sequences
Terminal Repeat Sequences
retrotransposons
Vertebrates
Genes
vertebrates
Proteins
genes
proteins
Retroviridae
Placenta
domestication
placenta
gag Genes
Biological Phenomena
Integrases
Immunity
Peptide Hydrolases
Cell proliferation

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chalopin, D., Hoover, M., Galiana, D., & Volff, J. N. (2012). LTR retroelement-derived protein-coding genes and vertebrate evolution. In Viruses: Essential Agents of Life (Vol. 9789400748996, pp. 269-282). Springer Netherlands. https://doi.org/10.1007/978-94-007-4899-6_13
Chalopin, Domitille ; Hoover, Marta ; Galiana, Delphine ; Volff, Jean Nicolas. / LTR retroelement-derived protein-coding genes and vertebrate evolution. Viruses: Essential Agents of Life. Vol. 9789400748996 Springer Netherlands, 2012. pp. 269-282
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Chalopin, D, Hoover, M, Galiana, D & Volff, JN 2012, LTR retroelement-derived protein-coding genes and vertebrate evolution. in Viruses: Essential Agents of Life. vol. 9789400748996, Springer Netherlands, pp. 269-282. https://doi.org/10.1007/978-94-007-4899-6_13

LTR retroelement-derived protein-coding genes and vertebrate evolution. / Chalopin, Domitille; Hoover, Marta; Galiana, Delphine; Volff, Jean Nicolas.

Viruses: Essential Agents of Life. Vol. 9789400748996 Springer Netherlands, 2012. p. 269-282.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Chalopin D, Hoover M, Galiana D, Volff JN. LTR retroelement-derived protein-coding genes and vertebrate evolution. In Viruses: Essential Agents of Life. Vol. 9789400748996. Springer Netherlands. 2012. p. 269-282 https://doi.org/10.1007/978-94-007-4899-6_13