Luminescence and photosensitivity of gadolinium labeled hematoporphyrin monomethyl ether

Peng Wang, Feng Qin, Li Wang, Fajun Li, Yangdong Zheng, Yunfei Song, Zhiguo Zhang, Wenwu Cao

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Photodynamic therapy for deep-lying lesions needs an appropriate imaging modality, precise evaluation of tissue oxygen and an effective photosensitizer. Gadolinium based metalloporphyrins Gd(III)- HMME is proposed in this study as a potential multifunctional theranostic agent, as photosensitizer, ratiometric oxygen sensor and MRI contrast agent. The time resolved spectroscopy revealed the luminescence peak of Gd(III)-HMME at 710 and 779 nm with a lifetime of 64 μs in oxygen-free methanol to be phosphorescent. This phosphorescence is strongly dependent on dissolved oxygen concentration. Its intensity in oxygen saturated methanol solution is 21% of that in deoxygenated solution. The singlet oxygen quantum yields F? of HMME and Gd(III)-HMME in air saturated methanol solution were determined to be 0.79 and 0.40 respectively using comparative spectra method. These phenomena indicate that the oxygen sensibility and production of singlet oxygen of Gd(III)-HMME can fulfill the requirement of PDT treatment.

Original languageEnglish (US)
Pages (from-to)2414-2422
Number of pages9
JournalOptics Express
Volume22
Issue number3
DOIs
StatePublished - Feb 10 2014

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

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