Lung cancer and the debrisoquine metabolic phenotype

Neil E. Caporaso, Margaret A. Tucker, Robert N. Hoover, Richard B. Hayes, Linda W. Pickle, Haleem J. Issaq, Gary M. Muschik, Laureen Green-gallo, Daina Buivys, Seena Aisner, James H. Resau, Benjamin F. Trump, David Tollerud, Aimsley Weston, Curtis C. Harris

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

In a case-control study, we tested the hypothesis that the genetically determined ability to metabolize debrisoquine is related to risk of lung cancer. Overall, individuals who were extensive metabolizers of debrisoquine were at significantly greater risk of lung cancer than those who were poor or intermediate metabolizers (odds ratio = 6.1; 95% confidence interval = 2.2-17.1). In this study, case patients had lung cancer, and control subjects had either chronic obstructive c pulmonary disease or cancers other than lung cancer. Results were adjusted for age, race, asbestos exposure, and smoking. Both black and white individuals who were extensive metab-olizers of debrisoquine were at significantly increased risk after similar adjustment (for blacks, odds ratio =4.5, 95% c confidence interval = 1.1-18.1; for whites, odds ratio =10.2, 95% confidence interval = 2.0-51.4). Significantly increased risk of lung cancer was also present for individuals who were extensive metabolizers when subjects with chronic obstruc- tive pulmonary disease or other cancers were considered separately. These data confirm that the ability to metabolize debrisoquine is a major determinant of susceptibility to lung cancer. Evaluation of the marker in other case-control I settings, further exploration of racial differences, and the prospective evaluation of this marker in subgroups at high risk of lung cancer are areas worthy of further study. [J Natl Cancer Inst 82: 1264-1272, 1990].

Original languageEnglish (US)
Pages (from-to)1264-1272
Number of pages9
JournalJournal of the National Cancer Institute
Volume82
Issue number15
DOIs
StatePublished - Aug 1 1990

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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