Lung cancer risk associated with cancer in relatives

Gail L. Shaw, Roni T. Falk, Linda Williams Pickle, Thomas T. Mason, Patricia A. Buffler

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Abstract

Family history data from an incident case-control study of lung cancer conducted in the Texas Gulf Coast region between 1976 and 1980 were analyzed to evaluate the contribution of cancer in first-degree relatives to lung cancer risk. Odds ratios (OR) increased slightly as the number of relatives with any cancer increased (reaching 1.5 with 4 or more relatives with cancer). Risks were higher for tobacco-related cancers (OR = 1.5 for 2 or more relatives with these tumors) and greatest for first-degree relatives with lung cancer (OR = 2.8 for lung cancer in 2 or more relatives). For cases of squamous cell carcinoma and adenocarcinoma of the lung, risks with 3 or more relatives with any cancer were increased 2-fold (OR = 1.8 and 1.9 respectively), and a significantly elevated risk was found for having a first-degree relative with lung cancer for each histologic type (ORs from 1.7-2.1). Having a spouse with lung cancer increased lung cancer risk (OR = 2.5), and cases with lung cancer reported in a first-degree relative were diagnosed at an earlier age, as were case siblings with lung cancer.

Original languageEnglish (US)
Pages (from-to)429-437
Number of pages9
JournalJournal of Clinical Epidemiology
Volume44
Issue number4-5
DOIs
Publication statusPublished - Jan 1 1991

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All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Shaw, G. L., Falk, R. T., Pickle, L. W., Mason, T. T., & Buffler, P. A. (1991). Lung cancer risk associated with cancer in relatives. Journal of Clinical Epidemiology, 44(4-5), 429-437. https://doi.org/10.1016/0895-4356(91)90082-K