Luteinizing hormone stimulates the production of prostacyclin by isolated ovarian cell in vitro

Johannes D. Veldhuis, Patricia Klase, Laurence Demers

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Granulosa cells isolated from mature Graafian follicles of swine produced significant quantities of immunoreactive 6-keto-PGF1α under chemically defined conditions in vitro. Luteinizing hormone elicited a dose-dependent stimulation of 6-keto-PGF1α accumulation, but follicle stimulating hormone, prolactin, L-epinephrine, estradiol-17B, or PGE2 were devoid of effect. The time-dependent in vitro production of 6-keto-PGF1α by ovarian cells was susceptible to inhibition by indomethacin, U-51506, cycloheximide, and actinomycin D. These observations implicate granulosa cells in the specific and hormonally regulated production of prostacyclin.

Original languageEnglish (US)
Pages (from-to)319-327
Number of pages9
JournalProstaglandins
Volume23
Issue number3
DOIs
StatePublished - Jan 1 1982

Fingerprint

Epoprostenol
Luteinizing Hormone
Granulosa Cells
Ovarian Follicle
Follicle Stimulating Hormone
Dactinomycin
Cycloheximide
Dinoprostone
Indomethacin
Prolactin
Epinephrine
Estradiol
Swine
In Vitro Techniques
prostaglandin F1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Cite this

Veldhuis, Johannes D. ; Klase, Patricia ; Demers, Laurence. / Luteinizing hormone stimulates the production of prostacyclin by isolated ovarian cell in vitro. In: Prostaglandins. 1982 ; Vol. 23, No. 3. pp. 319-327.
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Luteinizing hormone stimulates the production of prostacyclin by isolated ovarian cell in vitro. / Veldhuis, Johannes D.; Klase, Patricia; Demers, Laurence.

In: Prostaglandins, Vol. 23, No. 3, 01.01.1982, p. 319-327.

Research output: Contribution to journalArticle

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