Luteinizing hormone stimulates the production of prostacyclin by isolated ovarian cell in vitro

Johannes D. Veldhuis, Patricia Klase, Laurence M. Demers

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Granulosa cells isolated from mature Graafian follicles of swine produced significant quantities of immunoreactive 6-keto-PGF1α under chemically defined conditions in vitro. Luteinizing hormone elicited a dose-dependent stimulation of 6-keto-PGF1α accumulation, but follicle stimulating hormone, prolactin, L-epinephrine, estradiol-17B, or PGE2 were devoid of effect. The time-dependent in vitro production of 6-keto-PGF1α by ovarian cells was susceptible to inhibition by indomethacin, U-51506, cycloheximide, and actinomycin D. These observations implicate granulosa cells in the specific and hormonally regulated production of prostacyclin.

Original languageEnglish (US)
Pages (from-to)319-327
Number of pages9
JournalProstaglandins
Volume23
Issue number3
DOIs
StatePublished - Mar 1982

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Fingerprint Dive into the research topics of 'Luteinizing hormone stimulates the production of prostacyclin by isolated ovarian cell in vitro'. Together they form a unique fingerprint.

  • Cite this