Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes

Claudia Jakubzick, Milena Bogunovic, Anthony J. Bonito, Emma L. Kuan, Miriam Merad, Gwendalyn J. Randolph

Research output: Contribution to journalArticle

161 Scopus citations

Abstract

Observations that dendritic cells (DCs) constitutively enter afferent lymphatic vessels in many organs and that DCs in some tissues, such as the lung, turnover rapidly in the steady state have led to the concept that a major fraction of lymph node DCs are derived from migratory DCs that enter the lymph node through upstream afferent lymphatic vessels. We used the lysozyme M-Cre reporter mouse strain to assess the relationship of lymph node and nonlymphoid organ DCs. Our findings challenge the idea that a substantial proportion of lymph node DCs derive from the upstream tissue during homeostasis. Instead, our analysis suggests that nonlymphoid organ DCs comprise a major population of DCs within lymph nodes only after introduction of an inflammatory stimulus.

Original languageEnglish (US)
Pages (from-to)2839-2850
Number of pages12
JournalJournal of Experimental Medicine
Volume205
Issue number12
DOIs
StatePublished - Nov 12 2008

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes'. Together they form a unique fingerprint.

  • Cite this

    Jakubzick, C., Bogunovic, M., Bonito, A. J., Kuan, E. L., Merad, M., & Randolph, G. J. (2008). Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. Journal of Experimental Medicine, 205(12), 2839-2850. https://doi.org/10.1084/jem.20081430