Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats

Nancy Olsen, Wendell E. Nicholson, C. Rowan Debold, David N. Orth

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Cells of the immune system can produce and respond to peptide hormones associated with the endocrine system. However, the physiological significance of these endocrine- immune interactions is not known. It has been postulated that cells of the immune system, when stimulated with viruses that induce interferon-α, produce sufficient levels of ACTH to stimulate adrenal steroidogenesis and, thus, function as an auxiliary source of ACTH that may have a role in the response to stress, However, we have confirmed that levels of ACTH-related peptides produced by immunocompetent cells are far lower than those produced by the pituitary, raising questions about the ability of lymphocyte-derived ACTH to stimulate adrenal function. Furthermore, we have rigorously examined this issue using intact and hypophysectomized rate treated with Newcastle disease virus. Although high levels of interferon-α were produced by both intact and hypophysectomized rats, and the plasma corticosterone concentration increased dramatically in intact animals, corticosterone remained undetectable in hypophysectomized rats. The lack of a corticosterone response in these animals was not due to adrenal insensitivity to ACTH, as shown by a normal rise in corticosterone following Cosyntropin injection 8 h after hypophysectomy. The findings demonstrate that levels of ACTH produced by nonpituitary sources in response to viral infection are not sufficient to stimulate adrenal steroidogenesis.

Original languageEnglish (US)
Pages (from-to)2113-2119
Number of pages7
JournalEndocrinology
Volume130
Issue number4
DOIs
StatePublished - Jan 1 1992

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Adrenocorticotropic Hormone
Lymphocytes
Corticosterone
Interferons
Immune System
Cosyntropin
Newcastle disease virus
Hypophysectomy
Endocrine System
Peptide Hormones
Virus Diseases
Viruses
Peptides
Injections

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Olsen, Nancy ; Nicholson, Wendell E. ; Debold, C. Rowan ; Orth, David N. / Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats. In: Endocrinology. 1992 ; Vol. 130, No. 4. pp. 2113-2119.
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Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats. / Olsen, Nancy; Nicholson, Wendell E.; Debold, C. Rowan; Orth, David N.

In: Endocrinology, Vol. 130, No. 4, 01.01.1992, p. 2113-2119.

Research output: Contribution to journalArticle

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