Lymphocyte subsets in hemophilic patients with hepatitis C virus infection with or without human immunodeficiency virus co-infection: A nested cross-sectional study

Mingdong Zhang, Thomas R. O'Brien, William C. Kopp, James J. Goedert, P. S. Rosenberg, C. S. Rabkin, E. A. Engels, D. Whitby, M. E. Eyster, B. Konkle, M. Manco-Johnson, D. DiMichele, M. W. Hilgartner, P. Blatt, L. M. Aledort, S. Seremetes, K. Hoots, A. L. Angiolillo, N. L.C. Luban, A. CohenC. S. Manno, C. Leissinger, G. C. White, M. M. Lederman, S. Purvis, J. Salkowitz, C. M. Kessler, A. Karafoulidou, T. Mandalaki, A. Hatzakis, G. Touloumi, W. Schramm, F. Rommel, P. de Moerloose, S. Eichinger, K. E. Sherman, B. L. Kroner

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    Abstract

    Background: With chronic infection, hepatitis C virus (HCV) RNA can be detected in B cells and associated with B-cell disorders, but these are not well defined. Methods: The relationship between HCV infection and lymphocyte subpopulations was evaluated rigorously in 120 asymptomatic hemophilic patients, randomly selected from a prospective cohort study. CD4+ T cells, CD8+ T cells, CD19+ B cells, and CD56+ NK cells were quantified by flow cytometry using cryopreserved peripheral blood mononuclear cells of 24 hemophilic patients in each of five age-matched groups [uninfected; chronic HCV with or without human immunodeficiency virus (HIV); and cleared HCV with or without HIV]. Results: As expected, patients with HIV had significantly reduced CD4+ and increased CD8+ T cells. Irrespective of HIV, patients with chronic HCV infection had approximately 25% fewer CD19+ B cells than those without chronic HCV infection. Conclusions: These data support the hypothesis that asymptomatic patients with chronic HCV infection have an altered B-lymphocyte population.

    Original languageEnglish (US)
    JournalBMC Blood Disorders
    Volume5
    DOIs
    StatePublished - Jan 18 2005

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    All Science Journal Classification (ASJC) codes

    • Hematology
    • Molecular Biology

    Cite this

    Zhang, M., O'Brien, T. R., Kopp, W. C., Goedert, J. J., Rosenberg, P. S., Rabkin, C. S., Engels, E. A., Whitby, D., Eyster, M. E., Konkle, B., Manco-Johnson, M., DiMichele, D., Hilgartner, M. W., Blatt, P., Aledort, L. M., Seremetes, S., Hoots, K., Angiolillo, A. L., Luban, N. L. C., ... Kroner, B. L. (2005). Lymphocyte subsets in hemophilic patients with hepatitis C virus infection with or without human immunodeficiency virus co-infection: A nested cross-sectional study. BMC Blood Disorders, 5. https://doi.org/10.1186/1471-2326-5-2