Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Jeremy K. Haakenson, Andrei V. Khokhlatchev, Younhee J. Choi, Samuel S. Linton, Pu Zhang, Peter M. Zaki, Changliang Fu, Timothy K. Cooper, Andrea Manni, Junjia Zhu, Todd E. Fox, Cheng Dong, Mark Kester

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Abstract

Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

Original languageEnglish (US)
Pages (from-to)8632-8643
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
Publication statusPublished - Mar 27 2015

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Haakenson, J. K., Khokhlatchev, A. V., Choi, Y. J., Linton, S. S., Zhang, P., Zaki, P. M., ... Kester, M. (2015). Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells. Journal of Biological Chemistry, 290(13), 8632-8643. https://doi.org/10.1074/jbc.M114.609677