Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Jeremy K. Haakenson, Andrei V. Khokhlatchev, Younhee J. Choi, Samuel S. Linton, Pu Zhang, Peter M. Zaki, Changliang Fu, Timothy Cooper, Andrea Manni, Junjia Zhu, Todd E. Fox, Cheng Dong, Mark Kester

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

Original languageEnglish (US)
Pages (from-to)8632-8643
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
StatePublished - Mar 27 2015

Fingerprint

Anoikis
Ceramides
Cells
Carcinoma
Degradation
Neoplasms
Neoplasm Metastasis
Apoptosis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Haakenson, J. K., Khokhlatchev, A. V., Choi, Y. J., Linton, S. S., Zhang, P., Zaki, P. M., ... Kester, M. (2015). Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells. Journal of Biological Chemistry, 290(13), 8632-8643. https://doi.org/10.1074/jbc.M114.609677
Haakenson, Jeremy K. ; Khokhlatchev, Andrei V. ; Choi, Younhee J. ; Linton, Samuel S. ; Zhang, Pu ; Zaki, Peter M. ; Fu, Changliang ; Cooper, Timothy ; Manni, Andrea ; Zhu, Junjia ; Fox, Todd E. ; Dong, Cheng ; Kester, Mark. / Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 13. pp. 8632-8643.
@article{7e95b5733bc44cc09694ecb4749444f2,
title = "Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells",
abstract = "Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.",
author = "Haakenson, {Jeremy K.} and Khokhlatchev, {Andrei V.} and Choi, {Younhee J.} and Linton, {Samuel S.} and Pu Zhang and Zaki, {Peter M.} and Changliang Fu and Timothy Cooper and Andrea Manni and Junjia Zhu and Fox, {Todd E.} and Cheng Dong and Mark Kester",
year = "2015",
month = "3",
day = "27",
doi = "10.1074/jbc.M114.609677",
language = "English (US)",
volume = "290",
pages = "8632--8643",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "13",

}

Haakenson, JK, Khokhlatchev, AV, Choi, YJ, Linton, SS, Zhang, P, Zaki, PM, Fu, C, Cooper, T, Manni, A, Zhu, J, Fox, TE, Dong, C & Kester, M 2015, 'Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells', Journal of Biological Chemistry, vol. 290, no. 13, pp. 8632-8643. https://doi.org/10.1074/jbc.M114.609677

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells. / Haakenson, Jeremy K.; Khokhlatchev, Andrei V.; Choi, Younhee J.; Linton, Samuel S.; Zhang, Pu; Zaki, Peter M.; Fu, Changliang; Cooper, Timothy; Manni, Andrea; Zhu, Junjia; Fox, Todd E.; Dong, Cheng; Kester, Mark.

In: Journal of Biological Chemistry, Vol. 290, No. 13, 27.03.2015, p. 8632-8643.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

AU - Haakenson, Jeremy K.

AU - Khokhlatchev, Andrei V.

AU - Choi, Younhee J.

AU - Linton, Samuel S.

AU - Zhang, Pu

AU - Zaki, Peter M.

AU - Fu, Changliang

AU - Cooper, Timothy

AU - Manni, Andrea

AU - Zhu, Junjia

AU - Fox, Todd E.

AU - Dong, Cheng

AU - Kester, Mark

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

AB - Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

UR - http://www.scopus.com/inward/record.url?scp=84925710321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925710321&partnerID=8YFLogxK

U2 - 10.1074/jbc.M114.609677

DO - 10.1074/jbc.M114.609677

M3 - Article

C2 - 25681441

AN - SCOPUS:84925710321

VL - 290

SP - 8632

EP - 8643

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 13

ER -