Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology