Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Jeremy K. Haakenson; Andrei V. Khokhlatchev; Younhee J. Choi; Samuel S. Linton; Pu Zhang; Peter M. Zaki; Changliang Fu; Timothy K. Cooper; Andrea Manni; Junjia Zhu; Todd E. Fox; Cheng Dong; Mark Kester

doi:10.1074/jbc.M114.609677

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Jeremy K. Haakenson, Andrei V. Khokhlatchev, Younhee J. Choi, Samuel S. Linton, Pu Zhang, Peter M. Zaki, Changliang Fu, Timothy K. Cooper, Andrea Manni, Junjia Zhu, Todd E. Fox, Cheng Dong, Mark Kester

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

Original language	English (US)
Pages (from-to)	8632-8643
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	13
DOIs	https://doi.org/10.1074/jbc.M114.609677
State	Published - Mar 27 2015

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.609677

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Haakenson, J. K., Khokhlatchev, A. V., Choi, Y. J., Linton, S. S., Zhang, P., Zaki, P. M., Fu, C., Cooper, T. K., Manni, A., Zhu, J., Fox, T. E., Dong, C., & Kester, M. (2015). Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells. Journal of Biological Chemistry, 290(13), 8632-8643. https://doi.org/10.1074/jbc.M114.609677

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title = "Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells",

abstract = "Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.",

author = "Haakenson, {Jeremy K.} and Khokhlatchev, {Andrei V.} and Choi, {Younhee J.} and Linton, {Samuel S.} and Pu Zhang and Zaki, {Peter M.} and Changliang Fu and Cooper, {Timothy K.} and Andrea Manni and Junjia Zhu and Fox, {Todd E.} and Cheng Dong and Mark Kester",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

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day = "27",

doi = "10.1074/jbc.M114.609677",

language = "English (US)",

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Haakenson, JK, Khokhlatchev, AV, Choi, YJ, Linton, SS, Zhang, P, Zaki, PM, Fu, C, Cooper, TK, Manni, A , Zhu, J, Fox, TE, Dong, C & Kester, M 2015, 'Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells', Journal of Biological Chemistry, vol. 290, no. 13, pp. 8632-8643. https://doi.org/10.1074/jbc.M114.609677

TY - JOUR

T1 - Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

AU - Haakenson, Jeremy K.

AU - Khokhlatchev, Andrei V.

AU - Choi, Younhee J.

AU - Linton, Samuel S.

AU - Zhang, Pu

AU - Zaki, Peter M.

AU - Fu, Changliang

AU - Cooper, Timothy K.

AU - Manni, Andrea

AU - Zhu, Junjia

AU - Fox, Todd E.

AU - Dong, Cheng

AU - Kester, Mark

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

AB - Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

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U2 - 10.1074/jbc.M114.609677

DO - 10.1074/jbc.M114.609677

M3 - Article

C2 - 25681441

AN - SCOPUS:84925710321

SN - 0021-9258

VL - 290

SP - 8632

EP - 8643

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 13

ER -

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Abstract

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