Lyt‐Phenotype Conversion of Cytotoxic T Lymphocytes Specific for the A and E Class II Major Histocompatibility Complex Molecules

D. VIDOVIC, M. M. SIMON, Z. A. NAGY, J. KLEIN

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Abstract

The Lyt‐l + (high) Lyt‐2± (low) primary cytotoxic T lymphocytes (CTL) specific for A(AαAβ) molecules and the Lyt‐l +Lyt‐2+ primary E(EαEβ)‐specific CTL are both shown to become Lyt‐l Lyt‐2 + effector cells after secondary in vitro stimulation. Thus CTL specific for class II major histocompatibility complex molecules exhibit the same Lyt‐phenotype shift as class‐I‐specific CTL do. The data suggest that either both class‐I‐specific and class‐II‐specific CTL follow the same differentiation pathway or regulatory cellular interactions allow only Lyt‐l Lyt‐2+ cells to differentiate to secondary CTL.

Original languageEnglish (US)
Pages (from-to)583-586
Number of pages4
JournalScandinavian Journal of Immunology
Volume17
Issue number6
DOIs
StatePublished - Jun 1983

All Science Journal Classification (ASJC) codes

  • Immunology

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