M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression

Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae Il Choi, Ji Min Yang, Ju Young Kim, Young Chan Kim, Hyun Jai Cho, Jeffrey Maurice Peters, Seung Bum Ryoo, Young Tae Kim, Hyo Soo Kim

Research output: Contribution to journalArticle

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Abstract

We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARβ/δ activity in myeloid cells invitro and invivo. Myeloid cell-specific knockout of PPARβ/δ results in impaired growth of implanted tumors, and this is restored by adoptive transfer of wild-type myeloid cells. We find that IL-10 is a downstream effector of PPARβ/δ and facilitates tumor cell invasion and angiogenesis. This observation is supported by the finding that the CD11blowIL-10+ pro-tumoral myeloid cell is scarcely detected in tumors from myeloid-cell-specific PPARβ/δ knockout mice, where vessel densities are also decreased. Fatty acid synthase (FASN) is shown to be an upstream regulator of PPARβ/δ in myeloid cells and is induced by M-CSF secreted from tumor cells. Our study gives insight into how cancer cells influence myeloid stromal cells to get a pro-tumoral phenotype.

Original languageEnglish (US)
Pages (from-to)1614-1625
Number of pages12
JournalCell Reports
Volume10
Issue number9
DOIs
StatePublished - Mar 10 2015

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Fatty Acid Synthases
Peroxisome Proliferator-Activated Receptors
Macrophage Colony-Stimulating Factor
Myeloid Cells
Tumors
Chemical activation
Cells
Neoplasms
Stromal Cells
Crosstalk
Interleukin-10
Lewis Lung Carcinoma
Adoptive Transfer
Knockout Mice
Phenotype
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Park, Jonghanne ; Lee, Sang Eun ; Hur, Jin ; Hong, Eun Byeol ; Choi, Jae Il ; Yang, Ji Min ; Kim, Ju Young ; Kim, Young Chan ; Cho, Hyun Jai ; Peters, Jeffrey Maurice ; Ryoo, Seung Bum ; Kim, Young Tae ; Kim, Hyo Soo. / M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression. In: Cell Reports. 2015 ; Vol. 10, No. 9. pp. 1614-1625.
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abstract = "We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARβ/δ activity in myeloid cells invitro and invivo. Myeloid cell-specific knockout of PPARβ/δ results in impaired growth of implanted tumors, and this is restored by adoptive transfer of wild-type myeloid cells. We find that IL-10 is a downstream effector of PPARβ/δ and facilitates tumor cell invasion and angiogenesis. This observation is supported by the finding that the CD11blowIL-10+ pro-tumoral myeloid cell is scarcely detected in tumors from myeloid-cell-specific PPARβ/δ knockout mice, where vessel densities are also decreased. Fatty acid synthase (FASN) is shown to be an upstream regulator of PPARβ/δ in myeloid cells and is induced by M-CSF secreted from tumor cells. Our study gives insight into how cancer cells influence myeloid stromal cells to get a pro-tumoral phenotype.",
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Park, J, Lee, SE, Hur, J, Hong, EB, Choi, JI, Yang, JM, Kim, JY, Kim, YC, Cho, HJ, Peters, JM, Ryoo, SB, Kim, YT & Kim, HS 2015, 'M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression', Cell Reports, vol. 10, no. 9, pp. 1614-1625. https://doi.org/10.1016/j.celrep.2015.02.024

M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression. / Park, Jonghanne; Lee, Sang Eun; Hur, Jin; Hong, Eun Byeol; Choi, Jae Il; Yang, Ji Min; Kim, Ju Young; Kim, Young Chan; Cho, Hyun Jai; Peters, Jeffrey Maurice; Ryoo, Seung Bum; Kim, Young Tae; Kim, Hyo Soo.

In: Cell Reports, Vol. 10, No. 9, 10.03.2015, p. 1614-1625.

Research output: Contribution to journalArticle

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AU - Park, Jonghanne

AU - Lee, Sang Eun

AU - Hur, Jin

AU - Hong, Eun Byeol

AU - Choi, Jae Il

AU - Yang, Ji Min

AU - Kim, Ju Young

AU - Kim, Young Chan

AU - Cho, Hyun Jai

AU - Peters, Jeffrey Maurice

AU - Ryoo, Seung Bum

AU - Kim, Young Tae

AU - Kim, Hyo Soo

PY - 2015/3/10

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N2 - We investigate crosstalk between cancer cells and stromal myeloid cells. We find that Lewis lung carcinoma cells significantly induce PPARβ/δ activity in myeloid cells invitro and invivo. Myeloid cell-specific knockout of PPARβ/δ results in impaired growth of implanted tumors, and this is restored by adoptive transfer of wild-type myeloid cells. We find that IL-10 is a downstream effector of PPARβ/δ and facilitates tumor cell invasion and angiogenesis. This observation is supported by the finding that the CD11blowIL-10+ pro-tumoral myeloid cell is scarcely detected in tumors from myeloid-cell-specific PPARβ/δ knockout mice, where vessel densities are also decreased. Fatty acid synthase (FASN) is shown to be an upstream regulator of PPARβ/δ in myeloid cells and is induced by M-CSF secreted from tumor cells. Our study gives insight into how cancer cells influence myeloid stromal cells to get a pro-tumoral phenotype.

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