Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function

Emily Ling Lin Pai, Daniel Vogt, Alexandra Clemente-Perez, Gabriel L. McKinsey, Frances S. Cho, Jia Sheng Hu, Matt Wimer, Anirban Paul, Siavash Fazel Darbandi, Ramon Pla, Tomasz J. Nowakowski, Lisa V. Goodrich, Jeanne T. Paz, John L.R. Rubenstein

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.

Original languageEnglish (US)
Pages (from-to)1157-1173.e5
JournalCell Reports
Volume26
Issue number5
DOIs
StatePublished - Jan 29 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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