Magnetic resonance imaging and p‐31 magnetic resonance spectroscopy provide unique quantitative data useful in the longitudinal management of patients with dermatomyositis

Jane H. Park, Terri L. Vital, Nova M. Ryder, Marta Hernanz‐Schulman, C. Leon Partain, Ronald R. Price, Nancy J. Olsen

Research output: Contribution to journalArticle

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Abstract

Objective. To evaluate the utility of magnetic resonance imaging (MRI) and P‐31 magnetic resonance spectroscopy (MRS) in the longitudinal management of patients with dermatomyositis (DM). Methods. The study group consisted of 11 patients, including 3 children, all of whom had a clinical diagnosis of DM. A control group of 8 subjects was studied simultaneously. MRI included images as well as calculations of T1 and T2 relaxation times. The P‐31 MRS protocol evaluated metabolic status (i.e., inorganic phosphate/phosphocreatine ratios and phosphocreatine and ATP levels) during rest, exercise, and recovery. Results. T2‐weighted images of the thigh muscles showed inflammation even when serum creatine phosphokinase levels were in the normal range. Metabolic abnormalities, which were accentuated with exercise, were found in 10 patients. In some individuals, bioenergetic defects preceded other changes and persisted after resolution of inflammation. In general, clinical impressions correlated with MRI/MRS data. Conclusion. MRI and MRS provide unique data which are quantitative and which cannot be obtained from routine laboratory tests. These MR evaluations appear to be of value in assessing the status of DM patients during treatment with steroids and immuno‐suppressive drugs.

Original languageEnglish (US)
Pages (from-to)736-746
Number of pages11
JournalArthritis & Rheumatism
Volume37
Issue number5
DOIs
StatePublished - May 1994

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Dermatomyositis
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Phosphocreatine
Exercise
Inflammation
Immunosuppressive Agents
Creatine Kinase
Thigh
Energy Metabolism
Reference Values
Adenosine Triphosphate
Steroids
Phosphates
Muscles
Control Groups
Serum
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Park, Jane H. ; Vital, Terri L. ; Ryder, Nova M. ; Hernanz‐Schulman, Marta ; Leon Partain, C. ; Price, Ronald R. ; Olsen, Nancy J. / Magnetic resonance imaging and p‐31 magnetic resonance spectroscopy provide unique quantitative data useful in the longitudinal management of patients with dermatomyositis. In: Arthritis & Rheumatism. 1994 ; Vol. 37, No. 5. pp. 736-746.
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Magnetic resonance imaging and p‐31 magnetic resonance spectroscopy provide unique quantitative data useful in the longitudinal management of patients with dermatomyositis. / Park, Jane H.; Vital, Terri L.; Ryder, Nova M.; Hernanz‐Schulman, Marta; Leon Partain, C.; Price, Ronald R.; Olsen, Nancy J.

In: Arthritis & Rheumatism, Vol. 37, No. 5, 05.1994, p. 736-746.

Research output: Contribution to journalArticle

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