Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm

S. L. Arias, M. Alucozai, F. Pastrana, L. M. Reece, R. Kempaiah, J. J. Pavon, Jean Paul Allain

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aneurysm/pseudoaneurysm treatment requires a complete and definitive occlusion of the deffect from the parental artery to prevent bleeding. Current approaches such as coil embolization are still suboptimal for aneurysm sac occlusion, exhibiting various documented postsurgery recurrences. Asymetric bioactive stents with a magnetic surface able to attract magnetized cells may promote a rapid aneurysm treatment by bringing the aneurysm neck. An efficient cell internalization of nanoparticles is a perrequisite to address the feasiability of these approaches. In this study, cell magnetization using low pulse and low voltage electroporation parameters are assessed, and their effects on cell viability, genotoxicity, and nanoparticle internalization are shown.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages373-376
Number of pages4
StatePublished - Aug 9 2013
EventNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States
Duration: May 12 2013May 16 2013

Publication series

NameTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Volume3

Other

OtherNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
CountryUnited States
CityWashington, DC
Period5/12/135/16/13

All Science Journal Classification (ASJC) codes

  • Biotechnology

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    Arias, S. L., Alucozai, M., Pastrana, F., Reece, L. M., Kempaiah, R., Pavon, J. J., & Allain, J. P. (2013). Magnetic targeting of human aortic smooth muscle cells for rapid closure and healing of intracranial aneurysm/pseudoaneurysm. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (pp. 373-376). (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013; Vol. 3).