Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy

A. Fatemi, S. A. Smith, P. Dubey, K. M. Zackowski, A. J. Bastian, P. C. Van Zijl, H. W. Moser, Gerald Raymond, X. Golay

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: In adrenomyeloneuropathy (AMN) conventional MRI detects only spinal cord atrophy in the late stages. Objective: To apply a magnetization transfer-weighted (MTw) imaging to patients with AMN and AMN-like syndrome in order to visualize and quantitatively assess the pathology of white matter tracts in the cervical spinal cord. Methods: MTw studies were conducted in nine men with AMN, eight symptomatic heterozygous women, and 10 age- and sex-matched controls and compared to the Expanded Disability Status Scale (EDSS) and quantitative tests of vibratory sense and postural sway. MTw data sets were obtained at the level of C1 to C3 using a three-dimensional gradient echo acquisition technique, these images were then standardized between subjects by using the in-slice CSF signal as a normalization reference, allowing a quantitative assessment of the MTw signal. Results: In contrast to conventional MRI, MTw images showed signal hyperintensities in the lateral and dorsal columns of all patients. The MT signal quantified in the dorsal column showed significant differences between patients with AMN, X-linked adrenoleukodystrophy heterozygotes, and controls. MT hyperintensity in the dorsal column correlated with EDSS, vibratory sense, and postural sway. Conclusion: Magnetization transfer-weighted imaging is a sensitive modality for the visual and quantitative assessment of spinal cord pathology in adrenomyeloneuropathy, and is a potential tool for evaluation of new therapies.

Original languageEnglish (US)
Pages (from-to)1739-1745
Number of pages7
JournalNeurology
Volume64
Issue number10
DOIs
StatePublished - May 24 2005

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Adrenoleukodystrophy
Spinal Cord
Pathology
Heterozygote
Atrophy

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Fatemi, A., Smith, S. A., Dubey, P., Zackowski, K. M., Bastian, A. J., Van Zijl, P. C., ... Golay, X. (2005). Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy. Neurology, 64(10), 1739-1745. https://doi.org/10.1212/01.WNL.0000164458.02141.06
Fatemi, A. ; Smith, S. A. ; Dubey, P. ; Zackowski, K. M. ; Bastian, A. J. ; Van Zijl, P. C. ; Moser, H. W. ; Raymond, Gerald ; Golay, X. / Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy. In: Neurology. 2005 ; Vol. 64, No. 10. pp. 1739-1745.
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abstract = "Background: In adrenomyeloneuropathy (AMN) conventional MRI detects only spinal cord atrophy in the late stages. Objective: To apply a magnetization transfer-weighted (MTw) imaging to patients with AMN and AMN-like syndrome in order to visualize and quantitatively assess the pathology of white matter tracts in the cervical spinal cord. Methods: MTw studies were conducted in nine men with AMN, eight symptomatic heterozygous women, and 10 age- and sex-matched controls and compared to the Expanded Disability Status Scale (EDSS) and quantitative tests of vibratory sense and postural sway. MTw data sets were obtained at the level of C1 to C3 using a three-dimensional gradient echo acquisition technique, these images were then standardized between subjects by using the in-slice CSF signal as a normalization reference, allowing a quantitative assessment of the MTw signal. Results: In contrast to conventional MRI, MTw images showed signal hyperintensities in the lateral and dorsal columns of all patients. The MT signal quantified in the dorsal column showed significant differences between patients with AMN, X-linked adrenoleukodystrophy heterozygotes, and controls. MT hyperintensity in the dorsal column correlated with EDSS, vibratory sense, and postural sway. Conclusion: Magnetization transfer-weighted imaging is a sensitive modality for the visual and quantitative assessment of spinal cord pathology in adrenomyeloneuropathy, and is a potential tool for evaluation of new therapies.",
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Fatemi, A, Smith, SA, Dubey, P, Zackowski, KM, Bastian, AJ, Van Zijl, PC, Moser, HW, Raymond, G & Golay, X 2005, 'Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy', Neurology, vol. 64, no. 10, pp. 1739-1745. https://doi.org/10.1212/01.WNL.0000164458.02141.06

Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy. / Fatemi, A.; Smith, S. A.; Dubey, P.; Zackowski, K. M.; Bastian, A. J.; Van Zijl, P. C.; Moser, H. W.; Raymond, Gerald; Golay, X.

In: Neurology, Vol. 64, No. 10, 24.05.2005, p. 1739-1745.

Research output: Contribution to journalArticle

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AU - Fatemi, A.

AU - Smith, S. A.

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AU - Bastian, A. J.

AU - Van Zijl, P. C.

AU - Moser, H. W.

AU - Raymond, Gerald

AU - Golay, X.

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N2 - Background: In adrenomyeloneuropathy (AMN) conventional MRI detects only spinal cord atrophy in the late stages. Objective: To apply a magnetization transfer-weighted (MTw) imaging to patients with AMN and AMN-like syndrome in order to visualize and quantitatively assess the pathology of white matter tracts in the cervical spinal cord. Methods: MTw studies were conducted in nine men with AMN, eight symptomatic heterozygous women, and 10 age- and sex-matched controls and compared to the Expanded Disability Status Scale (EDSS) and quantitative tests of vibratory sense and postural sway. MTw data sets were obtained at the level of C1 to C3 using a three-dimensional gradient echo acquisition technique, these images were then standardized between subjects by using the in-slice CSF signal as a normalization reference, allowing a quantitative assessment of the MTw signal. Results: In contrast to conventional MRI, MTw images showed signal hyperintensities in the lateral and dorsal columns of all patients. The MT signal quantified in the dorsal column showed significant differences between patients with AMN, X-linked adrenoleukodystrophy heterozygotes, and controls. MT hyperintensity in the dorsal column correlated with EDSS, vibratory sense, and postural sway. Conclusion: Magnetization transfer-weighted imaging is a sensitive modality for the visual and quantitative assessment of spinal cord pathology in adrenomyeloneuropathy, and is a potential tool for evaluation of new therapies.

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Fatemi A, Smith SA, Dubey P, Zackowski KM, Bastian AJ, Van Zijl PC et al. Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy. Neurology. 2005 May 24;64(10):1739-1745. https://doi.org/10.1212/01.WNL.0000164458.02141.06