Maintenance of protein synthesis in hearts of diabetic animals

D. E. Rannels, Leonard "Jim" Jefferson, Å C. Hjalmarson, E. B. Wolpert, H. E. Morgan

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Abstract

Skeletal muscle of diabetic animals contained increased numbers of ribosomal subunits and decreased polysomes. However, numbers of polysomes and subunits in heart muscle 5 diabetic rats were the same as controls. Incorporation of14C-phenylalanine into protein of diabetic hearts occurred at the control rate. When control hearts were perfused, in vitro, with medium containing glucose and normal plasma levels of amino acids, polysomes decreased and subunits increased. These changes were prevented by addition of either insulin or palmitate suggesting that these factors facilitated peptide-chain initiation in heart muscle.

Original languageEnglish (US)
Pages (from-to)1110-1116
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume40
Issue number5
DOIs
Publication statusPublished - Sep 10 1970

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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