Maintenance of protein synthesis in hearts of diabetic animals

D. E. Rannels; L. S. Jefferson; Å C. Hjalmarson; E. B. Wolpert; H. E. Morgan

doi:10.1016/0006-291X(70)90909-5

Maintenance of protein synthesis in hearts of diabetic animals

D. E. Rannels, L. S. Jefferson, Å C. Hjalmarson, E. B. Wolpert, H. E. Morgan

Department of Cellular and Molecular Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

Skeletal muscle of diabetic animals contained increased numbers of ribosomal subunits and decreased polysomes. However, numbers of polysomes and subunits in heart muscle 5 diabetic rats were the same as controls. Incorporation of¹⁴C-phenylalanine into protein of diabetic hearts occurred at the control rate. When control hearts were perfused, in vitro, with medium containing glucose and normal plasma levels of amino acids, polysomes decreased and subunits increased. These changes were prevented by addition of either insulin or palmitate suggesting that these factors facilitated peptide-chain initiation in heart muscle.

Original language	English (US)
Pages (from-to)	1110-1116
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/0006-291X(70)90909-5
State	Published - Sep 10 1970

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0006-291X(70)90909-5

Cite this

@article{0c2f52b887f946359ebec05fabe27ffd,

title = "Maintenance of protein synthesis in hearts of diabetic animals",

abstract = "Skeletal muscle of diabetic animals contained increased numbers of ribosomal subunits and decreased polysomes. However, numbers of polysomes and subunits in heart muscle 5 diabetic rats were the same as controls. Incorporation of14C-phenylalanine into protein of diabetic hearts occurred at the control rate. When control hearts were perfused, in vitro, with medium containing glucose and normal plasma levels of amino acids, polysomes decreased and subunits increased. These changes were prevented by addition of either insulin or palmitate suggesting that these factors facilitated peptide-chain initiation in heart muscle.",

author = "Rannels, {D. E.} and Jefferson, {L. S.} and Hjalmarson, {{\AA} C.} and Wolpert, {E. B.} and Morgan, {H. E.}",

note = "Funding Information: *Supported by grants from The National Heart Institute and Life Insurance Medical Research Fund.",

year = "1970",

month = sep,

day = "10",

doi = "10.1016/0006-291X(70)90909-5",

language = "English (US)",

volume = "40",

pages = "1110--1116",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "5",

}

TY - JOUR

T1 - Maintenance of protein synthesis in hearts of diabetic animals

AU - Rannels, D. E.

AU - Jefferson, L. S.

AU - Hjalmarson, Å C.

AU - Wolpert, E. B.

AU - Morgan, H. E.

N1 - Funding Information: *Supported by grants from The National Heart Institute and Life Insurance Medical Research Fund.

PY - 1970/9/10

Y1 - 1970/9/10

N2 - Skeletal muscle of diabetic animals contained increased numbers of ribosomal subunits and decreased polysomes. However, numbers of polysomes and subunits in heart muscle 5 diabetic rats were the same as controls. Incorporation of14C-phenylalanine into protein of diabetic hearts occurred at the control rate. When control hearts were perfused, in vitro, with medium containing glucose and normal plasma levels of amino acids, polysomes decreased and subunits increased. These changes were prevented by addition of either insulin or palmitate suggesting that these factors facilitated peptide-chain initiation in heart muscle.

AB - Skeletal muscle of diabetic animals contained increased numbers of ribosomal subunits and decreased polysomes. However, numbers of polysomes and subunits in heart muscle 5 diabetic rats were the same as controls. Incorporation of14C-phenylalanine into protein of diabetic hearts occurred at the control rate. When control hearts were perfused, in vitro, with medium containing glucose and normal plasma levels of amino acids, polysomes decreased and subunits increased. These changes were prevented by addition of either insulin or palmitate suggesting that these factors facilitated peptide-chain initiation in heart muscle.

UR - http://www.scopus.com/inward/record.url?scp=0014940132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014940132&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(70)90909-5

DO - 10.1016/0006-291X(70)90909-5

M3 - Article

C2 - 5503786

AN - SCOPUS:0014940132

SN - 0006-291X

VL - 40

SP - 1110

EP - 1116

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 5

ER -

Maintenance of protein synthesis in hearts of diabetic animals

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this