TY - JOUR
T1 - Maintenance therapy for advanced non-small cell lung cancer
T2 - Current status, controversies, and emerging consensus
AU - Owonikoko, Taofeek K.
AU - Ramalingam, Suresh S.
AU - Belani, Chandra P.
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Maintenance therapy refers to the use of an active therapeutic agent for extended duration following frontline induction therapy for patients with advanced stage non-small cell lung cancer (NSCLC). Multiple clinical trials reported within the last few months have shown a beneficial role for maintenance therapy especially in select patient groups characterized by histology and/or molecular profile. With the recent approval by the U.S. Food and Drug Administration and European Medicines Agency of pemetrexed for maintenance therapy, a new treatment paradigm has been introduced to the treatment of NSCLC. This article reviews recent data with maintenance therapy in advanced NSCLC and discusses the implications for routine patient care and future drug development.
AB - Maintenance therapy refers to the use of an active therapeutic agent for extended duration following frontline induction therapy for patients with advanced stage non-small cell lung cancer (NSCLC). Multiple clinical trials reported within the last few months have shown a beneficial role for maintenance therapy especially in select patient groups characterized by histology and/or molecular profile. With the recent approval by the U.S. Food and Drug Administration and European Medicines Agency of pemetrexed for maintenance therapy, a new treatment paradigm has been introduced to the treatment of NSCLC. This article reviews recent data with maintenance therapy in advanced NSCLC and discusses the implications for routine patient care and future drug development.
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U2 - 10.1158/1078-0432.CCR-09-2328
DO - 10.1158/1078-0432.CCR-09-2328
M3 - Review article
C2 - 20388843
AN - SCOPUS:77951711337
VL - 16
SP - 2496
EP - 2504
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 9
ER -