Maintenance therapy for advanced non-small cell lung cancer: Current status, controversies, and emerging consensus

Taofeek K. Owonikoko, Suresh S. Ramalingam, Chandra P. Belani

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Maintenance therapy refers to the use of an active therapeutic agent for extended duration following frontline induction therapy for patients with advanced stage non-small cell lung cancer (NSCLC). Multiple clinical trials reported within the last few months have shown a beneficial role for maintenance therapy especially in select patient groups characterized by histology and/or molecular profile. With the recent approval by the U.S. Food and Drug Administration and European Medicines Agency of pemetrexed for maintenance therapy, a new treatment paradigm has been introduced to the treatment of NSCLC. This article reviews recent data with maintenance therapy in advanced NSCLC and discusses the implications for routine patient care and future drug development.

Original languageEnglish (US)
Pages (from-to)2496-2504
Number of pages9
JournalClinical Cancer Research
Volume16
Issue number9
DOIs
StatePublished - May 1 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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