Malaria parasite pre-erythrocytic infection: Preparation meets opportunity

Scott Eugene Lindner, Jessica L. Miller, Stefan H.I. Kappe

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

For those stricken with malaria, the classic clinical symptoms are caused by the parasite's cyclic infection of red blood cells. However, this erythrocytic phase of the parasite's life cycle initiates from an asymptomatic pre-erythrocytic phase: the injection of sporozoites via the bite of a parasite-carrying Anopheline mosquito, and the ensuing infection of the liver. With the increased capabilities of studying liver stages in mice, much progress has been made elucidating the cellular and molecular basis of the parasite's progression through this bottleneck of its life cycle. Here we review relevant findings on how sporozoites prepare for infection of the liver and factors crucial to liver stage development as well as key host/parasite interactions.

Original languageEnglish (US)
Pages (from-to)316-324
Number of pages9
JournalCellular Microbiology
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2012

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Malaria
Parasites
Sporozoites
Liver
Infection
Life Cycle Stages
Host-Parasite Interactions
Parasitic Diseases
Bites and Stings
Culicidae
Erythrocytes
Injections

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

Lindner, Scott Eugene ; Miller, Jessica L. ; Kappe, Stefan H.I. / Malaria parasite pre-erythrocytic infection : Preparation meets opportunity. In: Cellular Microbiology. 2012 ; Vol. 14, No. 3. pp. 316-324.
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Malaria parasite pre-erythrocytic infection : Preparation meets opportunity. / Lindner, Scott Eugene; Miller, Jessica L.; Kappe, Stefan H.I.

In: Cellular Microbiology, Vol. 14, No. 3, 01.03.2012, p. 316-324.

Research output: Contribution to journalReview article

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