Mammary gland development, reproductive history, and breast cancer risk

Lewis A. Chodosh, Celina M. D'Cruz, Heather Perry Gardner, Seung I. Ha, Sandra T. Marquis, Jayant V. Rajan, Douglas Stairs, James Y. Wang, Man Wang

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The observation that normal pathways of differentiation and development are invariably altered during the process of carcinogenesis implies an intrinsic relationship between these processes. This relationship is particularly evident in the breast, as exemplified by the existence of endocrine risk factors for breast cancer that are related to the timing of normal developmental events. Understanding the mechanisms by which normal developmental events alter breast cancer risk is a central focus of our laboratory. Herein, we describe three approaches being taken in our laboratory toward defining the molecular basis of this relationship. These include: determining the roles played by the tumor suppressor genes, BRCA1 and BRCA2, in the normal differentiation and development of the breast; studying the function of three novel protein kinases identified in our laboratory in mammary epithelial development; and defining the molecular and cellular changes that occur in the breast as a result of reproductive events known to influence breast cancer risk.

Original languageEnglish (US)
JournalCancer Research
Volume59
Issue number7 SUPPL.
StatePublished - Apr 1 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Chodosh, L. A., D'Cruz, C. M., Gardner, H. P., Ha, S. I., Marquis, S. T., Rajan, J. V., Stairs, D., Wang, J. Y., & Wang, M. (1999). Mammary gland development, reproductive history, and breast cancer risk. Cancer Research, 59(7 SUPPL.).