Mammary somatosensory pathways are not required for suckling-mediated inhibition of luteinizing hormone secretion and delay of ovulation in cows

G. L. Williams, Walter Roland McVey, Jr., J. F. Hunter

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Four experiments were conducted to evaluate endocrine, lactational, and reproductive features of an experimental animal model employing complete neural disconnection of the udder in beef cows and then to utilize the validated model to study the role of mammary somatosensory pathways in suckling-mediated anovulation. For experiment 1, crossbred beef cows (n = 16) were randomly assigned to suckled/sham-operated control, weaned (calf removed)/sham-operated control, and suckled/mammary-denervated groups between Days 14 and 18 postcalving. Ten additional cows were randomly divided into weaned or suckled unoperated control groups (experiment 2). Complete mammary anesthesia was attained in all denervated cows (experiment 1), but sensory perception was not affected in sham-operated controls. Prolactin release patterns were markedly depressed by denervation; however, oxytocin release, milk production, and calf growth rates were not affected. Although acute sham surgery attenuated weaning-induced increases in LH pulse and ovulation frequency (experiment 1), normal responses to weaning were observed in unoperated controls (experiment 2) as well as in sham-operated cows 1 yr later (experiment 3). Finally, denervated-suckled cows (n = 22) that had been denervated before conception (experiment 4) exhibited LH secretion patterns and mean postpartum intervals to luteal activity similar to those of intact- suckled cows (n = 16). In contrast, the intact-weaned group (n = 16; calves weaned at birth) responded within 2 wk postcalving with an increased frequency of LH pulses, and intervals to onset of luteal activity were shortened compared to those in the other groups. Suckling-mediated anovulation is not dependent upon mammary somatosensory cues.

Original languageEnglish (US)
Pages (from-to)1328-1337
Number of pages10
JournalBiology of reproduction
Volume49
Issue number6
DOIs
StatePublished - Nov 30 1993

Fingerprint

Luteinizing Hormone
Ovulation
Breast
Anovulation
Corpus Luteum
Weaning
Animal Mammary Glands
Denervation
Oxytocin
Prolactin
Postpartum Period
Cues
Milk
Anesthesia
Animal Models
Parturition
Control Groups
Inhibition (Psychology)
Growth

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Cell Biology

Cite this

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title = "Mammary somatosensory pathways are not required for suckling-mediated inhibition of luteinizing hormone secretion and delay of ovulation in cows",
abstract = "Four experiments were conducted to evaluate endocrine, lactational, and reproductive features of an experimental animal model employing complete neural disconnection of the udder in beef cows and then to utilize the validated model to study the role of mammary somatosensory pathways in suckling-mediated anovulation. For experiment 1, crossbred beef cows (n = 16) were randomly assigned to suckled/sham-operated control, weaned (calf removed)/sham-operated control, and suckled/mammary-denervated groups between Days 14 and 18 postcalving. Ten additional cows were randomly divided into weaned or suckled unoperated control groups (experiment 2). Complete mammary anesthesia was attained in all denervated cows (experiment 1), but sensory perception was not affected in sham-operated controls. Prolactin release patterns were markedly depressed by denervation; however, oxytocin release, milk production, and calf growth rates were not affected. Although acute sham surgery attenuated weaning-induced increases in LH pulse and ovulation frequency (experiment 1), normal responses to weaning were observed in unoperated controls (experiment 2) as well as in sham-operated cows 1 yr later (experiment 3). Finally, denervated-suckled cows (n = 22) that had been denervated before conception (experiment 4) exhibited LH secretion patterns and mean postpartum intervals to luteal activity similar to those of intact- suckled cows (n = 16). In contrast, the intact-weaned group (n = 16; calves weaned at birth) responded within 2 wk postcalving with an increased frequency of LH pulses, and intervals to onset of luteal activity were shortened compared to those in the other groups. Suckling-mediated anovulation is not dependent upon mammary somatosensory cues.",
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Mammary somatosensory pathways are not required for suckling-mediated inhibition of luteinizing hormone secretion and delay of ovulation in cows. / Williams, G. L.; McVey, Jr., Walter Roland; Hunter, J. F.

In: Biology of reproduction, Vol. 49, No. 6, 30.11.1993, p. 1328-1337.

Research output: Contribution to journalArticle

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