Management in patients with insulin-deficient diabetes

Kenneth Allan Freeman, Qian Wang, Peter Molenaar, Jan Ulbrecht, Carol H. Gold, Mike Rovine

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we propose and design an adaptive dual controller for automatic glucose control of diabetic patients. The results could be used in the development of an artificial pancreas, which, while as yet unavailable, must consist of three major components: an insulin delivery device or pump, a continuous glucose sensor, and a control algorithm linking insulin delivery to measured glucose concentration. For improved performance the system would also include feedforward information about food intake, physical activity and other blood glucose perturbing inputs. A linear time-varying autoregressive model with exogenous inputs is constructed to characterize the kinetics of both glucose-insulin and glucosecarbohydrate interaction. Combined with a Kalman-filter based estimation scheme for online estimation of the time-varying model coefficients, we design an adaptive dual control that both excites the glucose dynamic system sufficiently to accelerate the parameter estimation and cautiously tracks the desired glucose level. Performance evaluation of the adaptive dual controller is accomplished via simulations on virtual patients constructed using clinical data from five different patients with type-1 insulindeficient diabetes using continuous subcutaneous insulin infusion for diabetes management during observation. Simulation results show both smaller glucose excursions and a reduction in the number of hypoglycemic events for all but one of the five subjects.

Original languageEnglish (US)
Title of host publicationASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
Pages345-354
Number of pages10
DOIs
StatePublished - Dec 1 2012
EventASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012 - Fort Lauderdale, FL, United States
Duration: Oct 17 2012Oct 19 2012

Publication series

NameASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
Volume1

Other

OtherASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
CountryUnited States
CityFort Lauderdale, FL
Period10/17/1210/19/12

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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