Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis

Jonathan Stine, Patrick G. Northup

Research output: Contribution to journalReview article

Abstract

Non-tumoral portal vein thrombosis (PVT) remains a highly relevant topic in the field of hepatology and liver transplantation with much surrounding controversy. Although multiple studies have shown that PVT is associated with adverse outcomes with increased morbidity and mortality rates, others have not reported the same clinical impact of PVT, arguing rather that incident PVT reflects worsening portal hypertension and the natural history of the disease. Despite this uncertainly, PVT is a dilemma facing the clinician on a daily basis often requiring a multidisciplinary team-based approach between hepatologists, transplant surgeons, interventional radiologists and hematologists. In this review, the authors provide a summary of the evidence supporting best clinical practices in the management of non-tumoral PVT in patients with cirrhosis.

Original languageEnglish (US)
Pages (from-to)619-626
Number of pages8
JournalDigestive Diseases and Sciences
Volume64
Issue number3
DOIs
StatePublished - Mar 15 2019

Fingerprint

Portal Vein
Thrombosis
Fibrosis
Practice Management
Portal Hypertension
Gastroenterology
Practice Guidelines
Liver Transplantation
Morbidity
Transplants
Mortality

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

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title = "Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis",
abstract = "Non-tumoral portal vein thrombosis (PVT) remains a highly relevant topic in the field of hepatology and liver transplantation with much surrounding controversy. Although multiple studies have shown that PVT is associated with adverse outcomes with increased morbidity and mortality rates, others have not reported the same clinical impact of PVT, arguing rather that incident PVT reflects worsening portal hypertension and the natural history of the disease. Despite this uncertainly, PVT is a dilemma facing the clinician on a daily basis often requiring a multidisciplinary team-based approach between hepatologists, transplant surgeons, interventional radiologists and hematologists. In this review, the authors provide a summary of the evidence supporting best clinical practices in the management of non-tumoral PVT in patients with cirrhosis.",
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Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis. / Stine, Jonathan; Northup, Patrick G.

In: Digestive Diseases and Sciences, Vol. 64, No. 3, 15.03.2019, p. 619-626.

Research output: Contribution to journalReview article

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T1 - Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis

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AU - Northup, Patrick G.

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