Management of patients with low-grade liposarcoma, or atypical lipoma

G. Douglas Letson, Henry Wagner Jr., Carlos A. Muro-Cacho

Research output: Contribution to journalReview article

Abstract

Liposarcomas are a heterogeneous group of tumors with variable histopathology and clinical behavior. Accurate diagnosis, subtyping, and grading are essential to select appropriate treatment. We I-differentiated tumors are slow-growing and may reach large sizes without symptoms. They are considered local diseases with low metastatic potential but with a tender cy to recur and transform into aggressive sarcomas, To prevent excessive treatment of these indolent tumors, terms such "atypical lipomatous tumor" or "atypical lipoma" have been proposed, and although a consensus has not yet been reached, conservative surgical resection with attention to margins is favored. When negative margins are not obtained, adiotherapy may decrease local recurrence. Myxoid variants often metastasize and should be treated aggressively with surgery and judicious use of preoperative or postoperative radiotherapy. Resection of pulmonary metastases prolongs survival in selected patients. Chemotherapy benefits 25% of patients with metastatic or unresectable disease. Its optimal integration with local treatments in adjuvant or neoadjuvant settings is the focus of ongoing clinical trials.

Original languageEnglish (US)
Pages (from-to)454-460
Number of pages7
JournalCurrent Opinion in Orthopaedics
Volume13
Issue number6
DOIs
StatePublished - Dec 2002

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Liposarcoma
Lipoma
Neoplasms
Sarcoma
Radiotherapy
Therapeutics
Clinical Trials
Neoplasm Metastasis
Recurrence
Drug Therapy
Lung
Survival

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Letson, G. Douglas ; Wagner Jr., Henry ; Muro-Cacho, Carlos A. / Management of patients with low-grade liposarcoma, or atypical lipoma. In: Current Opinion in Orthopaedics. 2002 ; Vol. 13, No. 6. pp. 454-460.
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Management of patients with low-grade liposarcoma, or atypical lipoma. / Letson, G. Douglas; Wagner Jr., Henry; Muro-Cacho, Carlos A.

In: Current Opinion in Orthopaedics, Vol. 13, No. 6, 12.2002, p. 454-460.

Research output: Contribution to journalReview article

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AU - Wagner Jr., Henry

AU - Muro-Cacho, Carlos A.

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