Managing disappearing liver metastases following chemotherapy

Amanda Cooper, Thomas A. Aloia

Research output: Contribution to journalArticle

Abstract

Liver metastases that can no longer be identified on radiographic images after chemotherapy are termed disappearing metastases. This most commonly occurs in patients with multifocal bilobar metastases of differing size who are extensively treated with chemotherapy. The most effective treatment for disappearing liver metastases is prevention, through the use of high-quality pretreatment imaging, early involvement of a liver surgeon, and limitation of neoadjuvant chemotherapy to as few cycles as are needed for the metastases to become resectable. If a treated metastasis cannot be identified on CT, then MRI should be used to confirm a true disappearance. As the disappearance of a metastasis does not necessarily signify a pathologic complete response at that site, when possible, resection of liver metastases should include all sites that initially contained disease. If this is not possible, then these patients can be considered for other local therapies and should be followed closely for disease recurrence.

Original languageEnglish (US)
Pages (from-to)204-210
Number of pages7
JournalCurrent Colorectal Cancer Reports
Volume10
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Neoplasm Metastasis
Drug Therapy
Liver
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology
  • Hepatology

Cite this

@article{d6381f4e463c44e79faabe9d05577f89,
title = "Managing disappearing liver metastases following chemotherapy",
abstract = "Liver metastases that can no longer be identified on radiographic images after chemotherapy are termed disappearing metastases. This most commonly occurs in patients with multifocal bilobar metastases of differing size who are extensively treated with chemotherapy. The most effective treatment for disappearing liver metastases is prevention, through the use of high-quality pretreatment imaging, early involvement of a liver surgeon, and limitation of neoadjuvant chemotherapy to as few cycles as are needed for the metastases to become resectable. If a treated metastasis cannot be identified on CT, then MRI should be used to confirm a true disappearance. As the disappearance of a metastasis does not necessarily signify a pathologic complete response at that site, when possible, resection of liver metastases should include all sites that initially contained disease. If this is not possible, then these patients can be considered for other local therapies and should be followed closely for disease recurrence.",
author = "Amanda Cooper and Aloia, {Thomas A.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s11888-014-0215-8",
language = "English (US)",
volume = "10",
pages = "204--210",
journal = "Current Colorectal Cancer Reports",
issn = "1556-3790",
publisher = "Springer Science + Business Media",
number = "2",

}

Managing disappearing liver metastases following chemotherapy. / Cooper, Amanda; Aloia, Thomas A.

In: Current Colorectal Cancer Reports, Vol. 10, No. 2, 01.01.2014, p. 204-210.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Managing disappearing liver metastases following chemotherapy

AU - Cooper, Amanda

AU - Aloia, Thomas A.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Liver metastases that can no longer be identified on radiographic images after chemotherapy are termed disappearing metastases. This most commonly occurs in patients with multifocal bilobar metastases of differing size who are extensively treated with chemotherapy. The most effective treatment for disappearing liver metastases is prevention, through the use of high-quality pretreatment imaging, early involvement of a liver surgeon, and limitation of neoadjuvant chemotherapy to as few cycles as are needed for the metastases to become resectable. If a treated metastasis cannot be identified on CT, then MRI should be used to confirm a true disappearance. As the disappearance of a metastasis does not necessarily signify a pathologic complete response at that site, when possible, resection of liver metastases should include all sites that initially contained disease. If this is not possible, then these patients can be considered for other local therapies and should be followed closely for disease recurrence.

AB - Liver metastases that can no longer be identified on radiographic images after chemotherapy are termed disappearing metastases. This most commonly occurs in patients with multifocal bilobar metastases of differing size who are extensively treated with chemotherapy. The most effective treatment for disappearing liver metastases is prevention, through the use of high-quality pretreatment imaging, early involvement of a liver surgeon, and limitation of neoadjuvant chemotherapy to as few cycles as are needed for the metastases to become resectable. If a treated metastasis cannot be identified on CT, then MRI should be used to confirm a true disappearance. As the disappearance of a metastasis does not necessarily signify a pathologic complete response at that site, when possible, resection of liver metastases should include all sites that initially contained disease. If this is not possible, then these patients can be considered for other local therapies and should be followed closely for disease recurrence.

UR - http://www.scopus.com/inward/record.url?scp=84903693801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903693801&partnerID=8YFLogxK

U2 - 10.1007/s11888-014-0215-8

DO - 10.1007/s11888-014-0215-8

M3 - Article

VL - 10

SP - 204

EP - 210

JO - Current Colorectal Cancer Reports

JF - Current Colorectal Cancer Reports

SN - 1556-3790

IS - 2

ER -