Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy

Nipon Pothayee, Nikorn Pothayee, Nan Hu, Rui Zhang, Deb Kelly, Alan P. Koretsky, J. S. Riffle

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Novel manganese graft ionomer complexes (MaGICs) that contain Mn ions complexed with a polyaminobisphosphonate-g-poly(ethylene oxide) (PEO) copolymer were developed for use as T1-weighted contrast agents for MRI. The complexes exhibited good colloidal stability without release of free manganese and did not result in any in vitro toxicity against mouse hepatocytes. T 1 relaxivities of the MaGICs at physiological pH were 2-10 times higher than that of a commercial manganese-based positive contrast agent. Anticancer drugs including doxorubicin, cisplatin and carboplatin were successfully encapsulated into the MaGICs with high efficiency. Drug release behavior was sustained and depended on pH (faster in acidic environments), drug structures and drug concentration (faster with high concentration). The anticancer drug-loaded manganese nanocarriers exhibited excellent anticancer activity against MCF-7 breast cancer cells together with high relaxivity. Thus, these drug-loaded MaGICs could potentially be utilized for simultaneous diagnosis and treatment of cancer.

Original languageEnglish (US)
Pages (from-to)1087-1099
Number of pages13
JournalJournal of Materials Chemistry B
Volume2
Issue number8
DOIs
StatePublished - Feb 28 2014

Fingerprint

Chemotherapy
Ionomers
Manganese
Grafts
Imaging techniques
Pharmaceutical Preparations
Polyethylene oxides
Contrast Media
Carboplatin
Doxorubicin
Magnetic resonance imaging
Cisplatin
Toxicity
Copolymers
Cells
Ions

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Pothayee, N., Pothayee, N., Hu, N., Zhang, R., Kelly, D., Koretsky, A. P., & Riffle, J. S. (2014). Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy. Journal of Materials Chemistry B, 2(8), 1087-1099. https://doi.org/10.1039/c3tb21299h
Pothayee, Nipon ; Pothayee, Nikorn ; Hu, Nan ; Zhang, Rui ; Kelly, Deb ; Koretsky, Alan P. ; Riffle, J. S. / Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy. In: Journal of Materials Chemistry B. 2014 ; Vol. 2, No. 8. pp. 1087-1099.
@article{5046f9f201fe4ec0845ddc1645ec7e80,
title = "Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy",
abstract = "Novel manganese graft ionomer complexes (MaGICs) that contain Mn ions complexed with a polyaminobisphosphonate-g-poly(ethylene oxide) (PEO) copolymer were developed for use as T1-weighted contrast agents for MRI. The complexes exhibited good colloidal stability without release of free manganese and did not result in any in vitro toxicity against mouse hepatocytes. T 1 relaxivities of the MaGICs at physiological pH were 2-10 times higher than that of a commercial manganese-based positive contrast agent. Anticancer drugs including doxorubicin, cisplatin and carboplatin were successfully encapsulated into the MaGICs with high efficiency. Drug release behavior was sustained and depended on pH (faster in acidic environments), drug structures and drug concentration (faster with high concentration). The anticancer drug-loaded manganese nanocarriers exhibited excellent anticancer activity against MCF-7 breast cancer cells together with high relaxivity. Thus, these drug-loaded MaGICs could potentially be utilized for simultaneous diagnosis and treatment of cancer.",
author = "Nipon Pothayee and Nikorn Pothayee and Nan Hu and Rui Zhang and Deb Kelly and Koretsky, {Alan P.} and Riffle, {J. S.}",
year = "2014",
month = "2",
day = "28",
doi = "10.1039/c3tb21299h",
language = "English (US)",
volume = "2",
pages = "1087--1099",
journal = "Journal of Materials Chemistry B",
issn = "2050-7518",
publisher = "Royal Society of Chemistry",
number = "8",

}

Pothayee, N, Pothayee, N, Hu, N, Zhang, R, Kelly, D, Koretsky, AP & Riffle, JS 2014, 'Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy', Journal of Materials Chemistry B, vol. 2, no. 8, pp. 1087-1099. https://doi.org/10.1039/c3tb21299h

Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy. / Pothayee, Nipon; Pothayee, Nikorn; Hu, Nan; Zhang, Rui; Kelly, Deb; Koretsky, Alan P.; Riffle, J. S.

In: Journal of Materials Chemistry B, Vol. 2, No. 8, 28.02.2014, p. 1087-1099.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy

AU - Pothayee, Nipon

AU - Pothayee, Nikorn

AU - Hu, Nan

AU - Zhang, Rui

AU - Kelly, Deb

AU - Koretsky, Alan P.

AU - Riffle, J. S.

PY - 2014/2/28

Y1 - 2014/2/28

N2 - Novel manganese graft ionomer complexes (MaGICs) that contain Mn ions complexed with a polyaminobisphosphonate-g-poly(ethylene oxide) (PEO) copolymer were developed for use as T1-weighted contrast agents for MRI. The complexes exhibited good colloidal stability without release of free manganese and did not result in any in vitro toxicity against mouse hepatocytes. T 1 relaxivities of the MaGICs at physiological pH were 2-10 times higher than that of a commercial manganese-based positive contrast agent. Anticancer drugs including doxorubicin, cisplatin and carboplatin were successfully encapsulated into the MaGICs with high efficiency. Drug release behavior was sustained and depended on pH (faster in acidic environments), drug structures and drug concentration (faster with high concentration). The anticancer drug-loaded manganese nanocarriers exhibited excellent anticancer activity against MCF-7 breast cancer cells together with high relaxivity. Thus, these drug-loaded MaGICs could potentially be utilized for simultaneous diagnosis and treatment of cancer.

AB - Novel manganese graft ionomer complexes (MaGICs) that contain Mn ions complexed with a polyaminobisphosphonate-g-poly(ethylene oxide) (PEO) copolymer were developed for use as T1-weighted contrast agents for MRI. The complexes exhibited good colloidal stability without release of free manganese and did not result in any in vitro toxicity against mouse hepatocytes. T 1 relaxivities of the MaGICs at physiological pH were 2-10 times higher than that of a commercial manganese-based positive contrast agent. Anticancer drugs including doxorubicin, cisplatin and carboplatin were successfully encapsulated into the MaGICs with high efficiency. Drug release behavior was sustained and depended on pH (faster in acidic environments), drug structures and drug concentration (faster with high concentration). The anticancer drug-loaded manganese nanocarriers exhibited excellent anticancer activity against MCF-7 breast cancer cells together with high relaxivity. Thus, these drug-loaded MaGICs could potentially be utilized for simultaneous diagnosis and treatment of cancer.

UR - http://www.scopus.com/inward/record.url?scp=84893457004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893457004&partnerID=8YFLogxK

U2 - 10.1039/c3tb21299h

DO - 10.1039/c3tb21299h

M3 - Article

AN - SCOPUS:84893457004

VL - 2

SP - 1087

EP - 1099

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-7518

IS - 8

ER -