Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Jing Xie, Seneca L. Bessling, Timothy K. Cooper, Harry C. Dietz, Andrew S. McCallion, Shannon Fisher

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

Original languageEnglish (US)
Pages (from-to)1339-1342
Number of pages4
JournalGenetics
Volume176
Issue number2
DOIs
StatePublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Genetics

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