Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases

Jing Xie, Seneca L. Bessling, Timothy Cooper, Harry C. Dietz, Andrew S. McCallion, Shannon Fisher

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.

Original languageEnglish (US)
Pages (from-to)1339-1342
Number of pages4
JournalGenetics
Volume176
Issue number2
DOIs
StatePublished - Jun 1 2007

Fingerprint

RecQ Helicases
Zebrafish
Genetic Recombination
Embryonic Structures
DNA Helicases
Homologous Recombination
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Xie, J., Bessling, S. L., Cooper, T., Dietz, H. C., McCallion, A. S., & Fisher, S. (2007). Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics, 176(2), 1339-1342. https://doi.org/10.1534/genetics.107.072983
Xie, Jing ; Bessling, Seneca L. ; Cooper, Timothy ; Dietz, Harry C. ; McCallion, Andrew S. ; Fisher, Shannon. / Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. In: Genetics. 2007 ; Vol. 176, No. 2. pp. 1339-1342.
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Xie, J, Bessling, SL, Cooper, T, Dietz, HC, McCallion, AS & Fisher, S 2007, 'Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases', Genetics, vol. 176, no. 2, pp. 1339-1342. https://doi.org/10.1534/genetics.107.072983

Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. / Xie, Jing; Bessling, Seneca L.; Cooper, Timothy; Dietz, Harry C.; McCallion, Andrew S.; Fisher, Shannon.

In: Genetics, Vol. 176, No. 2, 01.06.2007, p. 1339-1342.

Research output: Contribution to journalArticle

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Xie J, Bessling SL, Cooper T, Dietz HC, McCallion AS, Fisher S. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 2007 Jun 1;176(2):1339-1342. https://doi.org/10.1534/genetics.107.072983